School of Genetics & Microbiology: Recent submissions
Now showing items 201-220 of 911
-
Activation of plasminogen by staphylokinase reduces the severity of Staphylococcus aureus systemic infection
(2010)Background. Staphylokinase (SAK) is produced by the majority of Staphylococcus aureus strains. It is an extracellular protein that activates the conversion of human plasminogen (plg) to plasmin. The role played by SAK in ... -
Design and characterisation of food grade powders and inks for microstructure control using 3D printing
(2018)Additive Manufacturing techniques have been previously applied to food materials with direct consumption in mind, as opposed to creating structural ingredients as shown in this study. First, semi-crystalline cellulose was ... -
The A domain of fibronectin-binding protein B of Staphylococcus aureus contains a novel fibronectin binding site.
(2011)The fibronectin‐binding proteins FnBPA and FnBPB are multifunctional adhesins than can also bind to fibrinogen and elastin. In this study, the N2N3 subdomains of region A of FnBPB were shown to bind fibrinogen with a similar ... -
The dipeptide repeat region of the fibrinogen-binding protein (clumping factor) is required for functional expression of the fibrinogen-binding domain on the Staphylococcus aureus cell surface.
(1997)Clumping factor of Staphylococcus aureus is a fibrinogen‐binding protein that is located on the bacterial cell surface. The protein has an unusual repeat domain (region R) comprising mainly the dipeptide aspartate and ... -
Involvement of the accessory gene regulator (agr) in expression of type 5 capsular polysaccharide by Staphylococcus aureus
(1993)The effect of an agr mutation on expression of type 5 capsular polysaccharide (CP) by Staphylococcus aureus Newman was investigated in different complex and synthetic media. CP expression by the agr mutant was strongly ... -
Modelling staphylococcal pneumonia in a human 3D lung tissue model system delineates toxin-mediated pathology
(2015)Staphylococcus aureus necrotizing pneumonia is recognized as a toxin-mediated disease, yet the tissue-destructive events remain elusive, partly as a result of lack of mechanistic studies in human lung tissue. In this study, ... -
Fluid Gels: a New Feedstock for High Viscosity Jetting
(2018)Suspensions of gel particles which are pourable or spoonable at room temperature can be created by shearing a gelling biopolymer through its gelation (thermal or ion mediated) rather than allowing quiescent cooling – thus ... -
Functional assessment of non-coding regulatory variants in familial breast cancer
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)Breast cancer is the most common cancer in Irish women, with almost 3,000 cases diagnosed every year. It often runs in families, and some women inherit a greater risk of developing the disease. Landmark studies on these ... -
Insufficient Evidence for "Autism-Specific" Genes
(2020)Despite evidence that deleterious variants in the same genes are implicated across multiple neurodevelopmental and neuropsychiatric disorders, there has been considerable interest in identifying genes that, when mutated, ... -
Investigating chromatin remodelling by the Swi-Snf and Tup1-Cyc8 complexes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)Swi-Snf is an ATP-dependent chromatin remodelling complex which generally acts as a co-activator of gene transcription via its removal of promoter nucleosomes. Conversely, Tup1-Cyc8 (Ssn6) is a co-repressor complex which ... -
De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences
(2020)Recent evidence demonstrates that novel protein-coding genes can arise de novo from non- genic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of non-genic transcripts, which ... -
Unravelling a food derived bioactive peptide with dual functionality of antimicrobial and immunomodulatory properties
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)In this thesis, a computational data mining and feature based approach to unravel the abundance of unexplored peptides from nature and to identify potent, novel antimicrobial peptides (AMPs) from phyto-proteins is proposed. ... -
Broad scale redistribution of mRNA abundance and transcriptional machinery in response to growth rate in Salmonella enterica serovar Typhimurium
(2017)We have investigated the connection between the four-dimensional architecture of the bacterial nucleoid and the organism's global gene expression programme. By localizing the transcription machinery and the transcriptional ... -
Control of virulence gene transcription by indirect readout in Vibrio cholerae and Salmonella enterica serovar Typhimurium
(2017)Indirect readout mechanisms of transcription control rely on the recognition of DNA shape by transcription factors (TFs). TFs may also employ a direct readout mechanism that involves the reading of the base sequence in the ... -
Faster Evolving Primate Genes Are More Likely to Duplicate
(2018)An attractive and long-standing hypothesis regarding the evolution of genes after duplication posits that the duplication event creates new evolutionary possibilities by releasing a copy of the gene from constraint. Apparent ... -
When is a transcription factor a NAP?
(2020)Proteins that regulate transcription often also play an architectural role in the genome. Thus, it has been difficult to define with precision the distinctions between transcription factors and nucleoid-associated proteins ... -
An Exploration of Mitochondrially Targeted Gene Therapies for Ocular Disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2020)Mitochondria play a vital role in numerous fundamental processes of the cell such as ATP synthesis, cellular signalling, reactive oxygen species production, calcium regulation and apoptosis to name but a few. Given their ... -
Consequences of exchanging the NAP-encoding genes fis and dps in Salmonella enterica Serovar Typhimurium
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2020)The genes encoding nucleoid associated proteins (NAPs) are syntenic among γ-Proteobacteria, and several factors are known to impact gene expression at a given locus, including changes in gene dosage caused by DNA replication. ... -
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
(2019)Background: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health ...
