School of Genetics & Microbiology: Recent submissions
Now showing items 521-540 of 911
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Production of biologically active IL-36 family cytokines through insertion of N-terminal caspase cleavage motifs
(2016)Recent evidence has strongly implicated IL-36 cytokines as key initiators of inflammation in the skin barrier. IL-36 cytokines belong to the extended IL-1 family and, similar to most members of this family, are expressed ... -
Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines
(2016)IL-36 cytokines require proteolytic processing for activation, but how this is achieved is unknown. Here, Henry et al. show that proteases liberated from activated neutrophils—cathepsin G, elastase, and proteinase-3 ... -
Studies of Streptococcus pneumoniae colonisation : role of capsule and induction of protective immunity
(Trinity College (Dublin, Ireland). Department of Microbiology, 2010)Streptococcus pneumoniae (the pneumococcus) is a major human pathogen responsible for an estimated 1.6 million deaths each year, most of which are of young children in the developing world. Current pneumococcal vaccines ... -
Explorations of miRNA expression in the mammalian retina
(Trinity College (Dublin, Ireland). Department of Genetics, 2009)MicroRNAs (miRs) are an abundant class of non-coding RNAs which, for the most part were undiscovered until early this decade (Lagos-Quintana et al. 2001; Lee et al. 2001). Mature miR transcripts are small (~22 nucleotides) ... -
Epidemiology of Streptococcus agalactiae (Group B Streptococci) in Dublin Maternity Hospitals
(Trinity College (Dublin, Ireland). Department of Microbiology, 2002)Streptococcus agalactiae (Group B Streptococci) are Gram-positive encapsulated cocci distinguished from other streptococci by their narrower zones of P-haemolysis. Group B Streptococci (GBS) was first described as an ... -
Function and evolution of genes in the human protein interaction network
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)The research conducted for this thesis aims to elucidate how the human protein interaction network has evolved, and how protein interactions influence the spatial organisation of the metabolic network. The thesis presents ... -
Evolution of vertebrate genome organisation
(Trinity College (Dublin, Ireland). Department of Genetics, 2002)The increasing availability of genomic sequences from different vertebrate organisms affords molecular biologists the opportunity to thoroughly investigate phenomena that were only hinted at by more sparse data. The work ... -
Genetic investigation of Irish ancestry and surname history
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)Several genetic systems were employed in this study to investigate Ireland’s pre-history and history. Initially Irish origins were examined using mtDNA sequence variation in 200 new samples coupled with an extensive novel ... -
Different patterns of gain and loss in genomic evolution
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Evolutionary forces may act on the genome at different levels, from the change of single nucleotides to the duplication or rearrangement of whole chromosomes. Some of these evolutionary processes can be responsible for ... -
Comparative analysis of poxvirus genome evolution
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)In this thesis I examine the molecular evolution of poxviruses using various comparative genomics approaches. Poxviruses are large DNA viruses that infect vertebrates and insects. Understanding the evolutionary processes ... -
Investigation of the immunophilin interactome of malarial parasites
(Trinity College (Dublin, Ireland). Department of Genetics, 2014)Malaria presents a significant global challenge in both human and economic terms. Approximately 40% of the population of the planet are at risk of contracting malaria, leading to an estimated 225 million cases and ... -
Re-engineering cellular physiology by rewiring high-level global regulatory genes
(2015)Knowledge of global regulatory networks has been exploited to rewire the gene control programmes of the model bacterium Salmonella enterica serovar Typhimurium. The product is an organism with competitive fitness that is ... -
The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.
(2015)PCGF1 encodes one of six human Polycomb RING finger homologs that are linked to transcriptional repression and developmental gene regulation. Individual PCGF proteins define discrete Polycomb Repressor Complex 1 (PRC1) ... -
Investigation of the transcriptional landscape and RNA biology of Salmonella Typhimurium plasmids
(Trinity College (Dublin, Ireland). Department of Microbiology, 2014) -
Diverse Activators of the NLRP3 Inflammasome Promote IL-1ß Secretion by Triggering Necrosis
(2015)The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing “signal I” and diverse agents such as ATP, Nigericin, ... -
MicroRNA profiling of the bovine alveolar macrophage response to Mycobacterium bovis infection suggests pathogen survival is enhanced by microRNA regulation of endocytosis and lysosome trafficking
(2015)Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first ... -
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
(2015)Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three ... -
Upper Palaeolithic genomes reveal deep roots of modern Eurasians.
(2015)We extend the scope of European palaeogenomics by sequencing the genomes of Late Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old, 15.4-fold) males from western Georgia in the Caucasus ...
