RSS 1.0Surgery
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Surgery (Live Theses)
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Surgery (Scholarly Publications)
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Surgery (Theses and Dissertations)
Surgery (Theses and Dissertations)
Recent Submissions
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Effectiveness of a low support, remotely accessible, cognitive remediation training programme for chronic psychosis: cognitive, functional and cortical outcomes from a single blind randomised controlled trial
(2018)Background. Cognitive remediation (CR) training has emerged as a promising approach to improving cognitive deficits in schizophrenia and related psychosis. The limited availability of psychological services for psychosis ... -
Investigating the role of miRNAs in the resistance of oesophago-gastric cancer to cytotoxic therapy
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2025)Oesophago-gastric cancers are two of the most commonly diagnosed cancers and the majority of oesophageal adenocarcinoma (OAC) and gastric adenocarcinoma (GAC) patients are diagnosed at a late stage. The standard of care ... -
Targeting DNA Damage Repair Deficiency in Pancreatic Cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, School of Medicine, 2024)Pancreatic ductal adenocarcinoma is a lethal disease with a 5-year survival of <12%. Approximately 5-10% of the patients have BRCA1/2 mutations which cause homologous recombination (HR) deficiency and sensitise to cisplatin ... -
Molecular mechanisms linking excess adipose tissue with esophageal cancer : targeting tumor metabolism and 5-lipoxygenase
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2017)Oesophageal adenocarcinoma (OAC) is the fastest growing cancer in the developed world. Visceral obesity, and in particular factors secreted from metabolically active visceral adipose tissue, may alter tumour glycolytic ... -
Towards fit for purpose final assessment of clinical skills in medical graduates
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2017)Background: The assessment of broader competencies of skills and attributes beyond knowledge are expected graduate outcomes in a medical degree. Assessment must provide explicit evidence of student learning. The quality ... -
Exploring the role of lipoxygenases in oesophageal cancer and the anti-angiogenic potential of novel lipoxgenase inhibitors
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Over the past decade there has been a dramatic increase in the incidence of oesophageal cancer in Ireland, which has the third highest incidence rate in Europe. This is mainly due to rising numbers of the oesophageal ... -
Investigation the role of T cells in the progression of reflux oesophagitis to Barrett's oesophagus and oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Oesophageal adenocarcinoma (OAC) is an inflammatory driven cancer that arises on a background of gastro-oesophageal reflux disease (GORD) and Barrett’s oesophagus (BO). T cells have been implicated in the initiation of ... -
The effect of cigarette smoking on inflammatory, immunological and metabolic profiles in ulcerative colitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Ulcerative Colitis (UC) is an idiopathic form of inflammatory bowel disease characterised by chronic or relapsing inflammation in the colon. The pathogenesis of UC remains largely unknown but it is widely believed to be ... -
Importance of energy metabolism, angiogenesis and DNA repair in regulating neoadjuvant radiosensitivity in oesophageal and rectal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Oesophageal and rectal adenocarcinoma are treated with neoadjuvant chemoradiotherapy in order to reduce tumour size prior to surgery, however only 10- 30% of patients have a complete pathological response and there are no ... -
Exploring the influence of obesity, fatty acids, and current treatment modalities on the immune-metabolic profiles of adipose tissue in oesophageal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Oesophageal adenocarcinoma (OAC) is a poor prognosis cancer with limited response rates to current standard of care treatments including chemotherapy and chemoradiotherapy. OAC has one of the strongest associations with ... -
Integrative multi-omic analytics for the early detection of pancreatic cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Pancreatic cancer (PC) has the lowest 5-year survival rate of any cancer, at just 12% in 2023. The poor survival rates observed in this cancer are the result of an accumulation of shortcomings and gaps in many aspects of ... -
Investigation of the role of the complement system in the radioresistance of rectal cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Colorectal cancer (CRC) is the third most common cancer globally, accounting for approximately 10% of all cancer diagnoses. A third of CRCs occur in the rectum. The majority of CRCs are diagnosed at advanced stages and ... -
Harnessing natural killer cell-mediated immune responses in obesity-associated cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Oesophagogastric adenocarcinomas (OAC) encompass a group of inflammation-driven and obesity-associated cancers. Poor 5-year survival rates of less than 20% and treatment response rates of less than 30% place these as poor ... -
Understanding the Role of MicroRNA-31 in Regulating Cellular Sensitivity to Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Pancreatic adenocarcinoma (PDAC) is a lethal malignancy with a poor survival rate. One main challenge regarding PDAC is resistance to chemotherapy and radiotherapy. Therefore, there is an urgent requirement to characterise ... -
C-reactive protein as a prognostic factor in cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Prognostication, the prediction of future outcomes, is a key aspect of cancer care but remains imprecise. An elevated serum C-reactive protein (CRP) is associated with high symptom burden, poor quality of life and shorter ... -
Investigating the Role of Altered Energy Metabolism in the Therapeutic Response of Rectal Cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Colorectal cancer (CRC) is the 3rd most commonly diagnosed cancer world-wide, accounting for an estimated 10% of all cancers diagnosed annually globally. One in three CRCs occur in the rectum. The standard of care for ... -
Combination radiotherapy and immunotherapy: effects on the immune landscape of oesophageal adenocarcinoma and the multimodal therapeutic paradigm
The incidence of cancer of the oesophagus and the gastro-oesophageal junction (GEJ) has increased exponentially in the western world over the last half century. Oesophageal adenocarcinoma (OAC) is now the dominant subtype, ... -
End-Of-Life Decision Making A Novel Entrustable Professional Activity?
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Introduction: Making tough decisions about End-Of-Life situations and palliative care in acute surgical scenarios is a non-technical skill surgeons have to master over a number of years of experience. Data suggests that ... -
Exercise-Based Dysphagia Rehabilitation for Adults with Oesophageal Cancer: a Systematic Review
(2022)Background: Dysphagia is prevalent in oesophageal cancer with significant clinical and psychosocial complications. The purpose of this study was i) to examine the impact of exercise-based dysphagia rehabilitation on clinical ... -
Investigating the applicability of immune checkpoint blockade in upper gastrointestinal cancers
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Oesophagogastric junctional adenocarcinoma (OGJ) is an aggressive malignancy with a high propensity to metastasise. Response rates to first-line chemo(radio)therapy regimens remain poor therefore, better treatment options ...
