| dc.contributor.author | MILLS, KINGSTON | |
| dc.date.accessioned | 2009-09-28T18:38:20Z | |
| dc.date.available | 2009-09-28T18:38:20Z | |
| dc.date.issued | 1998 | |
| dc.date.submitted | 1998 | en |
| dc.identifier.citation | Ryan, M. Murphy, G Nilsson, L., Shackley, F., Gothefors, L., ?mar, K., Miller, E. Storsaeter, J. and Mills, K.H.G. `Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children? in Immunology, 93, (1), 1998, pp 1-10 | en |
| dc.identifier.other | Y | |
| dc.identifier.other | Y | en |
| dc.description | PUBLISHED | en |
| dc.description.abstract | Recent clinical trials have demonstrated that new generation acellular pertussis vaccines can confer protection against whooping cough. However, the mechanism of protective immunity against Bordetella pertussis infection induced by vaccination remains to be defined. We have examined cellular immune responses in children immunized with a range of acellular and whole cell pertussis vaccines. Immunization of children with a potent whole-cell vaccine induced B. pertussis-specific T cells that secreted interferon-gamma (IFN-gamma), but not interleukin-5 (IL-5). In contrast, T cells from children immunized with acellular pertussis vaccines secreted IFN-gamma and/or IL-5 following stimulation with B. pertussis antigens in vitro. These observations suggest that protective immunity conferred by whole-cell vaccines, like natural immunity, is mediated by type 1 T cells, whereas the mechanism of immune protection generated with acellular vaccines may be more heterogeneous, involving T cells that secreted type 1 and type 2 cytokines. | en |
| dc.description.sponsorship | This work was supported by the Irish Health Research Board (project
grant number 100/94) and the National Institute of Health, USA
(grant number NOlA115125). | en |
| dc.format.extent | 1 | en |
| dc.format.extent | 10 | en |
| dc.format.extent | 1573057 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en | en |
| dc.publisher | British Society for Immunology | en |
| dc.relation.ispartofseries | Immunology | en |
| dc.relation.ispartofseries | 93 | en |
| dc.relation.ispartofseries | 1 | en |
| dc.rights | Y | en |
| dc.subject | Biochemistry | en |
| dc.title | Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/millsk | |
| dc.identifier.rssinternalid | 7722 | |
| dc.contributor.sponsor | Health Research Board | |
| dc.identifier.uri | http://hdl.handle.net/2262/33374 | |
