| dc.contributor.author | FARRAR, JANE | |
| dc.contributor.author | HUMPHRIES, PETER | |
| dc.date.accessioned | 2009-10-30T12:36:48Z | |
| dc.date.available | 2009-10-30T12:36:48Z | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008 | en |
| dc.identifier.citation | Reynolds, AL, Danciger, M, Farrar, GJ, Humphries, P, Kenna, PF `Influence of a quantitative trait locus on mouse chromosome 19 to the light-adapted electroretinogram? in Investigative Ophthalmology & Visual Science, 49, (9), 2008 | en |
| dc.identifier.other | Y | |
| dc.identifier.other | 58214 | |
| dc.identifier.other | Y | en |
| dc.description | PUBLISHED | en |
| dc.description.abstract | PURPOSE. Both implicit time and amplitude of the cone-mediated electroretinographic (ERG) b-wave differ significantly between the C57BL/6JOlaHsd and 129S2/SvHsd inbred mouse strains. The purpose of this work was to undertake a quantitative genetics study to localize the gene or genes involved.
METHODS. Implicit time and amplitude of the a- and b-waves of the single-flash and flicker cone-mediated ERG were recorded as the quantitative traits in reciprocal backcrossed populations. A genome-wide scan was performed with 106 polymorphic markers. Map Manager (release QTXb20) was used to analyze the data and make phenotype?genotype correlations.
RESULTS. A quantitative trait locus (QTL) of major effect in controlling variation in both implicit time and amplitude of the cone-mediated ERG localized to the middle of chromosome 19.
CONCLUSIONS. Mapping of a QTL influencing both implicit time and b-wave amplitude of the light-adapted ERG represents an initial step toward identifying the gene(s) responsible for this phenotypic variation. | en |
| dc.description.sponsorship | The Ocular Genetics Unit at Trinity College Dublin is supported
by Science Foundation Ireland, Fighting Blindness Ireland, European
Union 5th Framework Programme, HPRN CT200000098; the European
Union Evi-GenoRet, LSHG-CT-2005-512036; European Union (EU) RETNET
project (MRTN-CT-2003-504003), The British RP Society, and the
Health Research Board of Ireland. | en |
| dc.format.extent | 184546 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en | en |
| dc.publisher | Association for Research in Vision and Ophthalmology | en |
| dc.relation.ispartofseries | Investigative Ophthalmology & Visual Science | en |
| dc.relation.ispartofseries | 49 | en |
| dc.relation.ispartofseries | 9 | en |
| dc.rights | Y | en |
| dc.subject | Ophthalmology | |
| dc.title | Influence of a quantitative trait locus on mouse chromosome 19 to the light-adapted electroretinogram. | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/phumphrs | |
| dc.identifier.rssuri | http://dx.doi.org/10.1167/iovs.07-1620 | |
| dc.contributor.sponsor | Health Research Board | |
| dc.contributor.sponsor | Science Foundation Ireland | |
| dc.contributor.sponsor | European Union (EU) | |
| dc.identifier.uri | http://hdl.handle.net/2262/34427 | |
