dc.contributor.author | SCOTT, JOHN MARTIN | |
dc.date.accessioned | 2009-11-05T09:26:54Z | |
dc.date.available | 2009-11-05T09:26:54Z | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009 | en |
dc.identifier.citation | Hammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS, Murray L, Boreham CA, Scott JM, Mitchell LE, Whitehead AS `Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1? in Clinical Immunology, 133, (1), 2009, pp 132-137 | en |
dc.identifier.other | Y | en |
dc.identifier.other | Y | |
dc.identifier.other | 62100 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. Elevated homocysteine (hyperhomocysteinemia), which is usually associated with low-folate status, is a known risk factor for many pathologies with inflammatory etiologies. The present study was undertaken to examine whether there are associations between MCP-1 concentrations and folate/Hcy phenotype or methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype in healthy young adults. In females, MCP-1 concentrations were positively correlated with Hcy and negatively correlated with both serum and red blood cell folate; female smokers and MTHFR 677T carriers had particularly elevated MCP-1 concentrations. Similar relationships were not seen in males. These findings may have implications for understanding the female predominance observed for a range of autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. | en |
dc.description.sponsorship | This work was supported by the National Institutes of Health (NIH), Grant numbers: R01AR47663, P20RR020741, ES0P3013508, and R01HD039195; the Pennsylvania Department of Health, Grant number: 4100038714; and the British Heart Foundation. | en |
dc.format.extent | 166556 bytes | |
dc.format.extent | 132-137 | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.relation.ispartofseries | Clinical Immunology | en |
dc.relation.ispartofseries | 133 | en |
dc.relation.ispartofseries | 1 | en |
dc.rights | Y | en |
dc.subject | Immunology | en |
dc.title | Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/jscott | |
dc.identifier.rssuri | http://dx.doi.org/10.1016/j.clim.2009.06.008 | |
dc.contributor.sponsor | British Heart Foundation (BHF) | |
dc.contributor.sponsor | National Institutes of Health (NIH) | |
dc.identifier.uri | http://hdl.handle.net/2262/34508 | |