Pharmacology & Therapeutics: Recent submissions
Now showing items 21-40 of 87
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Metformin, aspirin, and colorectal cancer outcomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2013)Colorectal cancer is the second most incident cancer in men and women in Ireland and is the third greatest cause of cancer death. Metformin and aspirin, two drugs which are commonly used in type 2 diabetes and cardiovascular ... -
Prostate cancer pharmacoepidemiology : digoxin, aspirin and patient outcomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2013)Pharmacoepidemiology is the study of the effects of medicines in a real-world population; combining pharmacology, the study of medicines, with epidemiology the study of diseases. Prostate cancer is the most commonly diagnosed ... -
Pharmacoeconomics of Statin Therapy in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)Cardiovascular disease is the leading cause of death in most industrialised countries, including Ireland. Cholesterol lowering by pharmacological intervention prevents atherosclerotic plaque progression and has been shown ... -
Hippocampal long-term depression in anaesthetised adult rats: Involvement of glutamate and acetylcholine receptors
(Trinity College Dublin. School of Medicine. Discipline of Pharmacology & Therapeutics, 2017)Abstract: Hippocampal long-term depression in anaesthetised adult rats: Involvement of glutamate and acetylcholine receptors Kenneth J. O?Riordan Department of Pharmacology and Therapeutics School of Medicine, University ... -
Comorbidity and Type 2 Diabetes : prevalence, type and impact on cost and health-related behaviours
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2014)Comorbidity is the co-existence of one or more additional conditions in patients with a specified medical condition. It is highly prevalent in patients with diabetes and may be related (concordant) or unrelated (discordant) ... -
Multiple sclerosis in Ireland : costs, health-related quality of life and cost effectiveness of disease-modifying therapies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2014)This study aimed to evaluate the economic and health-related quality of life (HRQoL) burden of multiple sclerosis (MS) in Ireland, and to develop a framework for assessing the cost effectiveness of disease-modifying therapies ... -
Fasting plasma glucose as initial screening for diabetes and prediabetes in irish adults: The diabetes mellitus and vascular health initiative (DMVhi)
(2015)OBJECTIVE: Type 2 diabetes has a long pre clinical asymptomatic phase. Early detection may delay or arrest disease progression. The Diabetes Mellitus and Vascular health initiative (DMVhi) was initiated as a prospective ... -
Risk markers for acute stroke in Ireland - association of sodium-lithium countertransport (SLC) with vascular disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2002)The work in this thesis is divided into two parts, an epidemiological study of the risk markers for stroke in an Irish population and a laboratory study of the possible association between sodium lithium countertransport ... -
β-adrenoceptor-mediated regulation of matrix metalloproteinase-9 in fibroblasts
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2011)Adrenoceptor signalling in fibroblasts: Intracellular cAMP levels were measured by a direct cAMP enzyme immunoassay. Isoprenaline (ISO, 1 μM) increased intracellular cAMP concentration by 1.3 and 4.8 fold, P<0.05, after ... -
Health technology assessment in the Irish healthcare setting : application to oral anticoagulants
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)The objective of this thesis was to examine the application of economic evaluation within the Irish healthcare setting. In so doing, the author sought to develop skills in indirect comparison, economic modelling, value of ... -
Genetic polymorphisms and arterial stiffness
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as potential therapeutic ... -
Pharmacoepidemiology of diabetes mellitus in a national population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2010)Diabetes is associated with significant morbidity and mortality from microvascular and macrovascular complications. It is projected that the prevalence of diabetes will increase worldwide especially in the elderly population ... -
The use of the General Medical Services prescription database for pharmacoepidemiological studies in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)Pharmacoepidemiology may be divided into three main subdivisions, namely pharmacovigilence, drug utilisation and prescribing quality. An aim of this thesis was to demonstrate the usefulness of the General Medical Services ... -
Health economics in the Irish healthcare setting
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Economic analysis plays a key role in deciding which healthcare interventions should be made available in collectively funded healthcare systems. The aim of this thesis is to examine the application of health economics in ... -
Pharmaceutical pricing and reimbursement : an Irish perspective
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)There has been a five-fold increase in state expenditure on medicines under the Community Drug Schemes in Ireland over the last decade (1994 to 2004). As a result of this marked increase in pharmaceutical expenditure, the ... -
Nuclear receptor activation by antiretroviral drugs used in the treatment of HIV disease with implications for xenobiotic and endobiotic processes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2012)Genotyping: DNA was isolated from whole blood of 1013 HIV-patients and genotyped commercially for 37 single nucleotide polymorphisms (SNPs) and one 3-basepair insertion in genes of relevance for drug interactions: NR1I2 ... -
Stress and long-term potentiation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2001)Stress is a physiological reaction which the body copes with by a variety of mechanisms in order to restore homeostasis. Amongst these is an increase in plasma glucocorticoids, catecholamines and increases in brain ... -
Synaptic plasticity in animal models of stress : serotonergic mechanisms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)The inhibitory effect of acute elevated platform stress exposure on synaptic plasticity in the CA1 region of the hippocampus in vivo was investigated. Such stress exposure was confirmed to inhibit subsequent long term ...
