Increased glycolytic flux as an outcome of whole-genome duplication in yeast
Citation:
Conant, G.C. & Wolfe, K.H., Increased glycolytic flux as an outcome of whole-genome duplication in yeast, Molecular Systems Biology, 3, 129 , 2007Download Item:
Abstract:
After whole-genome duplication (WGD), deletions return most loci to single copy. However,
duplicate loci may survive through selection for increased dosage. Here, we show how the WGD
increased copy number of some glycolytic genes could have conferred an almost immediate selective
advantage to an ancestor of Saccharomyces cerevisiae, providing a rationale for the success of the
WGD. We propose that the loss of other redundant genes throughout the genome resulted in
incremental dosage increases for the surviving duplicated glycolytic genes. This increase gave post-
WGD yeasts a growth advantage through rapid glucose fermentation; one of this lineage?s many
adaptations to glucose-rich environments. Our hypothesis is supported by data from enzyme
kinetics and comparative genomics. Because changes in gene dosage follow directly from post-WGD
deletions, dosage selection can confer an almost instantaneous benefit after WGD, unlike
neofunctionalization or subfunctionalization, which require specific mutations. We also show
theoretically that increased fermentative capacity is of greatest advantage when glucose resources
are both large and dense, an observation potentially related to the appearance of angiosperms
around the time of WGD.
Sponsor
Grant Number
Science Foundation Ireland
Author's Homepage:
http://people.tcd.ie/khwolfeDescription:
PUBLISHED
Author: WOLFE, KENNETH
Sponsor:
Science Foundation IrelandPublisher:
BioMed CentralType of material:
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Series/Report no:
Molecular Systems Biology;3;
129;
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Full text availableKeywords:
Genetics, Saccharomyces cerevisiaeMetadata
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