RSS 1.0Psychiatry
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Psychiatry (Live Theses)
Psychiatry (Live Theses) -
Psychiatry (Scholarly Publications)
Psychiatry (Scholarly Publications) -
Psychiatry (Theses and Dissertations)
Psychiatry (Theses and Dissertations)
Recent Submissions
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Neurobiological and neuropsychological outcome of adults with a childhood diagnosis of Attention Deficit/Hyperactivity Disorder (ADHD)
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)There is a dearth of knowledge surrounding the neural mechanisms that determine the persistence or remission of ADHD into adulthood. Neuroimaging and neuropsychological studies have helped to better understand the biological ... -
Cortical Network Activity Predicts IGF-1 Treatment Response in Rett Syndrome
(2019)Background: Rett Syndrome is a neurodevelopment disorder associated with mutations in the gene MECP2, which is involved in the development and function of cortical networks. This dysfunction results in specific ... -
Exploring the Experience of Shame in Adult Survivors of Childhood Sexual Abuse Using a Mixed-Methods Approach
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)Childhood sexual abuse (CSA) is a worldwide problem that increases survivors' likelihood of experiencing a range of physical and mental health conditions. Survivors often feel, or are made to feel, shame surrounding their ... -
Rett syndrome and Fragile X: different etiology with common molecular dysfunctions
(2021)Rett syndrome (RTT) and Fragile X syndrome (FXS) are two monogenetic neurodevelopmental disorders with complex clinical presentations. RTT is caused by mutations in the Methyl-CpG binding protein 2 gene (MECP2) altering ... -
Molecular signatures of response to mecasermin in children with Rett Syndrome
(2022)Rett syndrome (RTT) is a devastating neurodevelopmental disorder without effective treatments. Attempts at developing targetted therapies have been relatively unsuccessful, at least in part, because the genotypical and ... -
Sex representation in neurodegenerative and psychiatric disorders' preclinical and clinical studies
(2023)Many studies show the importance of biological sex for the onset, progression, and response to treatment in brain disorders. In line with these reports, health agencies have requested that all trials, both at the clinical ... -
Development of trofinetide for the treatment of Rett syndrome: from bench to bedside
(2024)Rett syndrome (RTT) is rare neurodevelopmental disorder caused by mutations in the MECP2 gene that encodes methyl-CpG-binding protein 2 (MeCP2), a DNA-binding protein with roles in epigenetic regulation of gene expression. ... -
Rett syndrome in Ireland: a demographic study.
(2024)Background: Rett syndrome (RTT) is a rare neurodevelopmental condition associated with mutations in the gene coding for the methyl-CpG-binding protein 2 (MECP2). It is primarily observed in girls and affects individuals ... -
Mental Capacity for Treatment Decisions in Psychiatry Inpatients
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)This research aimed to assess the prevalence of mental capacity for treatment decisions in psychiatry inpatients in Ireland and elucidate the relationship, if any, between mental capacity and key clinical and demographic ... -
Exploring Neurocognitive Factors Underlying Autism and Hyperphagia in Prader-Willi Syndrome
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)Background: Prader-Willi Syndrome (PWS) is a rare complex multisystem genetic disorder recognised as the most common genetic cause of life-threatening obesity in humans (Butler, 1996). The PWS genotype gives rise to a ... -
Long-term outcomes following electroconvulsive therapy for treatment-resistant depression
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2016)Background: Electroconvulsive therapy (ECT) is the most acutely effective treatment for depression but its use is limited by high rates of early relapse and retrograde amnesia of uncertain severity and duration. Aims: ... -
Limbic System Development in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Longitudinal Multimodal MRI Analysis
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)While Attention-Deficit Hyperactivity Disorder (ADHD) is characterized by age-related changes in symptoms and brain structures during childhood and adolescence, the link between brain structure and function is less clear. ... -
Deep Learning for Neuroimaging: Advancing Brain-Based Biomarkers of Autism Spectrum Disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)In the last decade, deep learning (DL) has revolutionised fields like speech and vision through artificial neural networks. Can DL similarly transform biological psychiatry and neuroimaging? This thesis explores that ... -
The Contribution of Additional Genetic Variation to CNV Carrier Cognitive and Neurodevelopmental Outcomes
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Many copy number variants (CNV) are strongly associated with neurodevelopmental disorders (NDDs) such as autism, intellectual disability/developmental delay (ID/DD) and schizophrenia. CNVs are large genomic deletions or ... -
Coercion and Involuntary Care: A Study of Involuntary and Voluntary Psychiatry Inpatients in Dublin
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Involuntary care is a feature of mental health services around the world. In addition to involuntary admission and treatment, specific coercive or restrictive practices including seclusion and physical restraint occur in ... -
Neuroimaging to Assess Neonatal Brain Development and Brain Injury in Neonatal Encephalopathy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Neonatal encephalopathy (NE) is a clinical syndrome describing perinatal brain injury and neurological dysfunction in the term-born infant. Magnetic resonance imaging (MRI) is a widely used tool in the assessment of NE, ... -
Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders
Second generation antipsychotics (SGAs) are used in children and adolescents to treat psychotic symptoms in Early Onset Psychosis (EOP) and irritability and behaviours that challenge in autism spectrum disorder (ASD). ... -
Developing pedigree-based strategies to analyse whole genome sequencing data for complex disorders: learning from schizophrenia
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Complex genetic disorders are impacted by a range of DNA variation. Next generation sequencing (NGS) allows for the direct examination of this variation, but large sample numbers are required to identify rare variants in ... -
BRAIN: Brain Injury in Neonates
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Despite advances in neonatal care leading to a dramatic reduction in mortality rates in recent decades, there have been comparatively modest improvements in neurodevelopmental outcomes for infants born with neonatal ...
