School of Medicine: Recent submissions
Now showing items 701-720 of 3444
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Out-of-pocket costs near end of life in low- and middle-income countries: A systematic review
(2022)Background Globally, there is a rise in chronic disease, including cancer, major organ failure and dementias. Patients and their families in low- and middle-income countries (LMICs) pay a high proportion of medical costs ... -
Health and social care near the end of life: Can policies reduce costs and improve outcomes?
(WHO Regional Office for Europe, 2021) -
Enhancing the implementation of the Making Every Contact Count brief behavioural intervention programme in Ireland: protocol for the Making MECC Work research programme
(Health Research Board, 2022)Background: Brief behavioural interventions offered by healthcare professionals to target health behavioural risk factors (e.g. physical activity, diet, smoking and drug and alcohol use) can positively impact patient health ... -
The Complexities of Antimicrobial Resistance in Acute Care: An Exploration of Key Actors and Factors Associated with Acute Care Antimicrobial Stewardship
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background Antimicrobial resistance (AMR) is an evolving global healthcare emergency, of which a significant driver is the use and overuse of antimicrobials. Antimicrobial stewardship (AMS) is a multi-component, multidisciplinary ... -
Maternal prenatal anxiety, depression and stressful life events and trajectories of cardiometabolic risk factors across childhood and adolescence: a prospective cohort study
(2021)Objectives: Quantifying long-term offspring cardiometabolic health risks associated with maternal prenatal anxiety and depression can guide cardiometabolic risk prevention. This study examines associations between maternal ... -
An application of PRECIS-2 to evaluate trial design in a pilot cluster randomised controlled trial of a community-based smoking cessation intervention for women living in disadvantaged areas of Ireland
(2022)“We Can Quit2” (WCQ2) was a pilot cluster randomised controlled trial with an embedded process evaluation assessing the feasibility and acceptability of ‘We Can Quit’ (WCQ), a peer-delivered community-based stop-smoking ... -
On dignity in inpatient psychiatric care
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Dignity is an important concept in human rights legislation and medical ethics but is under-studied in psychiatric settings. It is a nuanced concept which is considered difficult to define, but nevertheless has a prominent ... -
A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma
(2022)Aims: We have recently described a novel guanidinium-based compound, VP79s, which induces cytotoxicity in various cancer cell lines. Here, we aim to investigate the activity of VP79s and associated mechanisms of action in ... -
Variation in clinical outcomes and immune consequences following two viral infections
Ageing is associated with increasing rates of ill-health. However, the burden of ill-health is not evenly distributed across ageing populations. The term biological age captures the consequences of ageing more effectively ... -
A scoping review of the changing landscape of Geriatric Medicine in undergraduate medical education: curricula, topics and teaching methods
(2021)Purpose: The world’s population is ageing. Therefore, every doctor should receive geriatric medicine training during their undergraduate education. This review aims to summarise recent developments in geriatric medicine ... -
Exploring bi-directional temporal associations between timed-up-and-go and cognitive domains in The Irish Longitudinal Study on Ageing (TILDA)
(2022)Introduction: The bi-directional longitudinal associations between mobility and cognition in older adults are poorly understood. Our objective was to study the temporal associations between timed-up-and-go (TUG) and five ... -
Recurrence of venous thromboembolism in patients with gynaecological cancer incidence, risk factors and impact on survival
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Background: Gynaecological malignancy and surgery are independently associated with the highest risks of VTE. However, factors influencing the rate of recurrent VTE in patients with gynaecological malignancy are unknown. ... -
Implications of Cardiovascular Ageing for Cerebral Perfusion and Cognitive Performance
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)The aim of this thesis is to examine how common manifestations of cardiovascular ageing, Orthostatic Hypotension and Atrial Fibrillation, affect cerebral perfusion and cognitive function in Irish adults. Associations between ... -
An Evaluation of the End-of-Life Programme
(2012)This executive summary will explain the remit of the evaluation undertaken and its associated methods; review some of the key findings and recommendations that emerged; and explain what the reader will find in the report’s ... -
Advancing the Economics of Palliative Care: The Value to Individuals and Families, Organizations, and Society
(2021)Current research assessing the economic outcomes of palliative care is limited, and policymakers, payers, patients and clinicians need more information to appropriately and systematically implement palliative care in the ... -
Investigating the phenotype and functional roles of human liver-resident natural killer (NK) cells
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2021)The human liver is an immunologically complex organ populated with distinct resident immune cells including liver-resident CD56bright NK (lrNK) cells which have a distinct CD69+CXCR6+T-betloEomeshi phenotype. These ... -
A systematic review of persistent symptoms and residual abnormal functioning following acute COVID-19: Ongoing symptomatic phase vs. post-COVID-19 syndrome
(2021)Objective: To compare the two phases of long COVID, namely ongoing symptomatic COVID-19 (OSC; signs and symptoms from 4 to 12 weeks from initial infection) and post-COVID-19 syndrome (PCS; signs and symptoms beyond 12 ... -
A linear regression-based machine learning pipeline for the discovery of clinically relevant correlates of gait speed reserve from multiple physiological systems
(2021)Frailty in older adults is characterized by reduced physiological reserve. Gait speed reserve (GSR: maximum minus usual gait speed) could help identify frailty and act as a proxy for physiological reserve. Utilizing data ... -
Alluvial visualization and computation of probabilities of transitions in frailty index states over an 8-year period using multi-state Markov models
(2021)The Frailty Index (FI) is an operationalization of frailty in older adults based on the accumulation of health deficits. FI cut-offs define the non-frail, prefrail and frail states. We described longitudinal transitions ...
