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dc.contributor.authorHARRIS, JAMES
dc.date.accessioned2011-02-15T18:23:08Z
dc.date.available2011-02-15T18:23:08Z
dc.date.issued2010
dc.date.submitted2010en
dc.identifier.citationJames Harris, Joseph Keane, How tumour necrosis factor blockers interfere with tuberculosis immunity., Clinical and Experimental Immunology, 161, 1, 2010, 1 - 9en
dc.identifier.otherY
dc.descriptionPUBLISHEDen
dc.description.abstractTumour necrosis factor (TNF) is a potent inflammatory cytokine that plays an important role in immunity to numerous bacterial infections, including Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) in humans. Infliximab, adalimumab, certolizumab pegol and etanercept are anti-TNF agents used to treat a range of inflammatory/autoimmune diseases, such as rheumatoid arthritis. The use of some of these drugs has been linked to reactivation TB. In addition to blocking TNF-mediated immune responses, some anti-TNF drugs have been found to interfere with innate immune responses, such as phagolysosomal maturation and monocyte apoptosis, as well as cell-mediated responses, including interferon-? secretion by memory T cells, complement-mediated lysis of Mtb-reactive CD8+ T cells and increased regulatory T cell activity. This review summarizes some of the reported effects of TNF blockers on immune cell responses in the context of the observed clinical data on TB reactivation in patients on anti-TNF therapy.en
dc.description.sponsorshipBoth authors are supported by Science Foundation Ireland (SFI) as part of the Immunology Research Centre, SFI Strategic Research Cluster. J. H. was supported in part by a grant from the Irish Lung Foundation. J. K. is funded by an HRB CSA award and the Royal City of Dublin Hospital Trust.en
dc.format.extent1en
dc.format.extent9en
dc.language.isoenen
dc.publisherJohn Wileyen
dc.relation.ispartofseriesClinical and Experimental Immunology;
dc.relation.ispartofseries161;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectImmunologyen
dc.subjectMycobacterium tuberculosisen
dc.titleHow tumour necrosis factor blockers interfere with tuberculosis immunity.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/jaharris
dc.identifier.rssinternalid70987
dc.identifier.rssurihttp://dx.doi.org/10.1111/j.1365-2249.2010.04146.xen
dc.identifier.urihttp://hdl.handle.net/2262/50589


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