Browsing Medical Gerontology by Sponsor "Health Research Board (HRB)"
Now showing items 1-20 of 30
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Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA)
(2021)Objective: To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged ... -
Altered lives in a time of crisis: The impact of the COVID-19 pandemic on the lives of older adults in Ireland. Findings from The Irish Longitudinal Study on Ageing
(TILDA, 2021)The ongoing pandemic of SARS-CoV-2, a novel coronavirus that causes COVID-19 infection and disease, is threatening healthcare systems globally as well as in Ireland. (1) The COVID-19 pandemic, and public health-associated ... -
The bi-directional association between loneliness and depression among older adults from before to during the COVID-19 pandemic.
(2023)Background: Older adults have both the highest risk of contracting SARS-CoV-2 and in many jurisdictions have had additional restrictions placed on the social interactions. As a result, the COVID-19 pandemic has led to ... -
Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults
(2023)Background: There is a need for effective primary care interventions that help older people combat frailty and build resilience. Objective: To study the effectiveness of an optimised exercise and dietary protein ... -
Childhood Circumstances and Mid-life Functional Mobility
(2016)Objectives: We examine the cumulative long-term role of childhood health and socioeconomic status in affecting functional health at ages 50 to 59. Method: Data on 2,233 respondents to The Irish Longitudinal Study of ... -
Clustering of behavioural symptoms and their associations with cognitive decline in older adults
(2020)Objectives: To examine (i) the clustering of reduced falls-efficacy, social withdrawal and physical activity withdrawal in Irish adults aged 50 years and older, and (ii) the concurrent and prospective associations of these ... -
Comparing Underlying and Contributory Cause of Death in Registry Data With End-of-Life Proxy Interviews: Findings From The Irish Longitudinal Study on Ageing (TILDA)
(2020)Cause of death is an important outcome in end-of-life (EOL) research. However, difficulties in assigning cause of death have been well documented. We compared causes of death in national death registrations with those ... -
Depressive symptoms among older adults pre- and post- COVID-19 pandemic
(2021)Objectives: It is a concern that public health measures to prevent older people contracting COVID-19 could lead to a rise in mental health problems such as depression. The aim of this study therefore is to examine trends ... -
Determinants of Physical Activity Engagement and Physical Activity Intervention Adherence in Individuals with Mild Cognitive Impairment: A Mixed Methods Study
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2022)The overarching aim of this thesis was to to identify the determinants of PA engagement and PA intervention adherence in individuals with MCI to expand on this under-researched topic and better inform PA promotion and ... -
The Effects of Acute and Chronic Exercise on Brain Derived Neurotrophic Factor and Cognitive Performance in Mild Cognitive Impairment
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2019)Introduction: Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that supports neural survival, growth and synaptic plasticity and is upregulated through exercise. While the exact neuronal mechanisms underlying the ... -
How does socio-economic position (SEP) get biologically embedded? A comparison of allostatic load and the epigenetic clock(s)
(Elsevier, 2019)Individuals of lower socio-economic position (SEP) carry a heavier burden of disease and morbidity and live shorter lives on average compared with their more advantaged counterparts. This has sparked research interest in ... -
The Importance of Proximity to Death in Modelling Community Medication Expenditures for Older People: Evidence From New Zealand
(2014)BACKGROUND: Concerns about the long-term sustainability of health care expenditures (HCEs), particularly prescribing expenditures, has become an important policy issue in most developed countries. Previous studies suggest ... -
In their own words: The voices of Older Irish people in the COVID-19 pandemic
(The Irish Longitudinal Study on Ageing, Trinity College Dublin, 2021)Since COVID-19 was declared an international pandemic by the World Health Organisation (WHO) in March 2020 (HSE, 2021), older people have carried the greatest burden of serious infection and death from the virus. ... -
The Lasting Legacy of Childhood Adversity for Disease Risk In Later Life
(2015)Objective: There has been an increased interest in the role of the childhood social environment in the etiology of adult diseases in recent years. The present study examines whether the experience of adversity during ... -
Linking death registration and survey data: Procedures and cohort profile for The Irish Longitudinal Study on Ageing
(2020)Background: Research on mortality at the population level has been severely restricted by an absence of linked death registration and survey data in Ireland. We describe the steps taken to link death registration information ... -
Maternal educational inequalities in measured body mass index trajectories in three European countries
(2019)Background: Social inequalities in the prevalence of childhood overweight and obesity are well‐established, but less is known about when the social gradient first emerges and how it evolves across childhood and ... -
Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults
(2021)In this Specialty Grand Challenge, we outline our vision of the current challenges in the field of Network Physiology as applied to aging and frailty. An expected development in this field for the 21st century is the ... -
Obesity is associated with reduced cerebral blood flow - modified by physical activity
(2021)This study examined the associations of body mass index (BMI), waist-to-hip ratio (WHR), waist circum- ference (WC), and physical activity (PA) with gray matter cerebral blood flow (CBFGM ) in older adults. Cross-sectional ...
