Medical Gerontology: Recent submissions
Now showing items 261-280 of 529
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Frequency of Long QT in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine: a Meta-analysis
(2020)Introduction: Hydroxychloroquine (HCQ) has been proposed as a SARS-CoV-2 treatment but the frequency of long QT (LQT) during use is unknown. Objective: To conduct a meta-analysis of the frequency of LQT in patients with ... -
Change in skeletal muscle associated with unplanned hospital admissions in adult patients: a systematic review and meta-analysis
(2019)Objectives: The primary objective of the review was to describe change that occurs in skeletal muscle during periods of unplanned hospitalisation in adult patients. The secondary objective was to examine the relationship ... -
Eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA): stability and clinical associations after 4 years
(2021)Previous research cross-sectionally characterised eight morphological systolic blood pres-sure (SBP) active stand (AS) patterns using a clinical clustering approach at Wave 1 (W1) of the IrishLongitudinal Study on Ageing. ... -
Health and social factors associated with a delayed discharge amongst inpatients in acute geriatric wards: A retrospective observational study
(2018)Aim: In the English National Health Service there is an increasing interest in understanding the factors associated with delayed discharges in older hospitalized adults. The present study sought to analyze whether clinical ... -
Impairments in Hemodynamic Responses to Orthostasis Associated with Frailty: Results from The Irish Longitudinal Study on Ageing (TILDA)
(2018)Objectives: To characterize the relationships between orthostatic blood pressure (BP) and heart rate recovery and frailty in an older population. Design: Cross-sectional study. Setting: Two health centers in the Republic ... -
Anticholinergic medications in patients admitted with cognitive impairment and falls (AMiCI). The impact of hospital admission on anticholinergic cognitive medication burden. Results of a multi centre observational study
(2018)What is known and objective: Drugs with anticholinergic properties increase the risk of falls, delirium, chronic cognitive impairment, and mortality and counteract procholinergic medications used in the treatment of dementia. ... -
Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity
(2020)The excellent review by Al-Ani et al reflects a consensus approach to management of inflammatory bowel disease during the SARS-CoV-2 pandemic that has been established remarkably rapidly by very effective international ... -
Preventing vitamin D deficiency during the COVID-19 pandemic: UK definitions of vitamin D sufficiency and recommended supplement dose are set too low
(2021)There is growing evidence linking vitamin D deficiency with risk of COVID-19. It is therefore distressing that there is major disagreement about the optimal serum level for 25-hydroxyvitamin D (25(OH)D) and appropriate ... -
Orthostatic hypotension and novel blood pressure associated gene variants in older adults: data from the TILDA Study
(2020)Orthostatic hypotension (OH) is associated with increased risk of trauma and cardiovascular events. Recent studies have identified new genetic variants that influence orthostatic blood pressure (BP). The aim of this study ... -
Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: Implications for COVID-19
(2021)The value of vitamin D supplementation in the treatment or prevention of various conditions is often viewed with scepticism as a result of contradictory results of randomised trials. It is now becoming apparent that there ... -
New Insights and Knowledge on Cognition and Dementia from Population-Based Cohort of Older Adults in India.
(2020)The Longitudinal Aging Study in India (LASI) is the world's largest aging survey, a groundbreaking nationally representative longitudinal survey to examine aging and retirement among India's aged 45 and older population. ... -
Potentially inappropriate medication use in older adults with mild-moderate Alzheimer's disease: prevalence and associations with adverse events.
(2020)Aim: Potentially inappropriate medication (PIM) use is prevalent in older adults and is associated with adverse events, hospitalisation and mortality. We assessed the patterns and associations of PIM use in older adults ... -
Physical activity partially mediates associations between ¿Big¿ personality traits and incident generalized anxiety disorder: Findings from the irish longitudinal study on ageing
(Elsevier BV, 2020)Background: This study aimed to examine associations of personality with generalized anxiety disorder (GAD) and physical activity (PA), PA with GAD, and PA mediates associations between personality and incident GAD. Methods: ... -
Does the choice of Allostatic Load scoring algorithm matter for predicting age-related health outcomes?
(2020)Allostatic Load (AL) is posited to provide a measure of cumulative physiological dysregulation across multiple biological systems and demonstrates promise as a sub-clinical marker of overall health. Despite the large ... -
Risk Factors for Incident Dementia Among Older Cubans.
(2020)Introduction: Little is known about risk factors of dementia in Latin American countries. We aimed to identify socio–demographic, health and lifestyle risk factors of incident dementia in Cuban older adults. Methods: Data ... -
Increased Salt Intake for Orthostatic Intolerance Syndromes: A Systematic Review and Meta-Analysis.
(2020)Guidelines recommend increased salt intake as a first-line recommendation in the management of symptomatic orthostatic hypotension and recurrent syncope. There have been no systematic reviews of this intervention. We sought ... -
Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis.
(2020)SARS‐CoV‐2 coronavirus infection ranges from asymptomatic through to fatal COVID‐19 characterized by a ‘cytokine storm’ and lung failure. Vitamin D deficiency has been postulated as a determinant of severity. -
A High Prevalence of Vitamin D Deficiency Observed in an Irish South East Asian Population: A Cross-sectional Observation Study
(2020)At northern latitudes, non-ethnic population groups can be at an increased risk of vitamin D deficiency (defined as a 25-hydroxyvitamin D [25(OH)D] status ≤30 nmol/L). The vitamin D status of ethnic minority groups has ... -
Approximate entropies of resting state continuous neurocardiovascular physiological signals are associated with physical frailty in older adults
(2021)Frailty in older adults is characterised by dysregulation in multiple physiological systems. The frailty phenotype is defined on the basis of exhaustion, unexplained weight loss, weakness, slowness and low physical activity ... -
Severity and Mortality of SARS-COV-2 infection and 25-hydroxyvitamin D concentration: a metanalysis
(2021)Introduction: There is increasing scientific interest in the possible association between hypovitaminosis D and the risk of SARS-CoV-2 infection severity and/or mortality. Objective: To conduct a metanalysis of the ...
