Biochemistry: Recent submissions
Now showing items 141-160 of 1067
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Cyclosporine A modulates CD103+ DC responses to fungal PAMPs
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Cyclosporine A (CsA) is an immunosuppressant that protects against inflammatory diseases and graft rejection. Despite its strong efficacy, one side-effect of CsA is an increased risk of fungal infection. To minimise this, ... -
Modulation of prostaglandin production by indole-3-pyruvate and 4-octyl itaconate in proinflammatory
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)The recent surge in immunometabolism research has revealed how specific changes in the level of metabolites can affect the immune response. One important feature of the immune response is the production of a class of lipid ... -
Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver
(2021)5-Aminolevulinic acid (ALA) is the rate-limiting intermediate in heme biosynthesis in vertebrate species; a re- action catalyzed by the mitochondrial ALA synthase 1 (ALAS1) enzyme. Previously we reported that knockdown of ... -
The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi?bi mechanism
(2020)Eukaryotic tRNA-guanine transglycosylase (TGT) – an enzyme recently recognised to be of potential therapeutic importance – catalyses base-exchange of guanine for queuine at the wobble position of tRNAs associated with ... -
Queuine micronutrient deficiency promotes warburg metabolism and reversal of the mitochondrial ATP synthase in hela cells
(2020)ueuine is a eukaryotic micronutrient, derived exclusively from eubacteria. It is incorporated into both cytosolic and mitochondrial transfer RNA to generate a queuosine nucleotide at position 34 of the anticodon loop. The ... -
A non-toxic, reversibly released imaging probe for oral cancer that is derived from natural compounds.
(2021)CD44 is emerging as an important receptor biomarker for various cancers. Amongst these is oral cancer, where surgical resection remains an essential mode of treatment. Unfortunately, surgery is frequently associated with ... -
CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages
(2021)SARM1 is a toll/interleukin-1 receptor -domain containing protein, with roles proposed in both innate immunity and neuronal degeneration. Murine SARM1 has been reported to regulate the transcription of chemokines in both ... -
Next generation SARM1 knockout and epitope tagged CRISPR-Cas9-generated isogenic mice reveal that SARM1 does not participate in regulating nuclear transcription, despite confirmation of protein expression in macrophages
(2021)ABSTRACT SARM1 is an ancient and highly conserved TIR-domain containing protein, with a diverse range of proposed roles in both innate immunity and neuronal death and degeneration. Murine SARM1 has been reported to ... -
The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity.
(2021)Base-modification can occur throughout a transfer RNA molecule; however, elaboration is particularly prevalent at position 34 of the anticodon loop (the wobble position), where it functions to influence protein translation. ... -
Sex differences regulate immune responses in experimental autoimmune encephalomyelitis and multiple sclerosis
(2022)MS is an autoimmune disease of the CNS that afflicts over 2.5 million people world-wide. There are striking sex differences in the susceptibility to and progression of thisdisease in humans. Females are twice as likely to ... -
Interactions Between Systemic Inflammation, Frailty And Neuroinflammation In Ageing And Neurodegeneration
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Compelling evidence continues to define the pivotal role which inflammation plays in the progression of neurodegenerative diseases and ageing. It has emerged that inflammation outside the brain significantly contributes ... -
Functional Relevance of Interleukin 8 Haplotype for the Innate Immune System in Holstein-Friesian Cattle
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Calves rely heavily on their innate immune response in the post-birth period before their adaptive immune system develops. Interleukin 8 (IL-8) is a major chemoattractant predominantly associated with neutrophils response ... -
The activation of unconventional T cells by Staphylococcus aureus
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Staphylococcus aureus is a major human pathogen of multiple tissue sites. The emergence of antibiotic-resistant strains promises greater morbidity in the future. No S. aureus vaccine has so far succeeded in translating ... -
IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F + neutrophils
(2021)Understanding the mechanism of protective immunity in the nasal mucosae is central to the design of more effective vaccines that prevent nasal infection and transmission of Bordetella pertussis. We found significant ... -
The Effects of Trained Innate Immunity on T Cell Responses; Clinical Implications and Knowledge Gaps for Future Research
(2021)The burgeoning field of innate immune training, also called trained immunity, has given immunologists new insights into the role of innate responses in protection against infection and in modulating inflammation. Moreover, ... -
Correction: IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils
(2021)The original version of this article unfortunately contained a mistake in Fig. 3h. Due to a typesetting error the lines on the graph have been moved below the X axis. We apologize for this error. The correct Fig. 3h can ... -
Overcoming waning immunity in pertussis vaccines: Workshop of the national institute of allergy and infectious diseases
(2020)Despite high vaccine coverage in many parts of the world, pertussis is resurging in a number of areas in which acellular vaccines are the primary vaccine administered to infants and young children. This is attributed in ... -
Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells
(2020)Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this ... -
Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors
(2021)It remains unresolved how retinal pigment epithelial cell metabolism is regulated following immune activation to maintain retinal homeostasis and retinal function. We exposed retinal pigment epithelium (RPE) to several ... -
Type ii nkt cell agonist, sulfatide, is an effective adjuvant for oral heat-killed cholera vaccines
(2021)Oral vaccination has the potential to offer a safer and more efficacious approach for protection against enteric pathogens than injection-based approaches, especially in developing countries. One key advantage is the ...
