Browsing Biochemistry by Title
Now showing items 1-20 of 1067
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2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype
(2019)Due to limited availability of pharmacological therapies, triple-negative breast cancer (TNBC) is the subtype with worst outcome. We hypothesised that 2-Deoxy-D-Glucose (2-DG), a glucose analogue, may hold potential as a ... -
2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC)
(Portland Press, 1997)The metal chelator and anti-oxidant pyrollidine dithiocarbamate (PDTC) has been used extensively in studies implicating reactive oxygen intermediates in the activation of nuclear factor kappa B (NF kappa B). In agreement ... -
3-Vinylazetidin-2-Ones: Synthesis, antiproliferative and tubulin destabilizing activity in MCF-7 and MDA-MB-231 Breast Cancer Cells
(MDPI, 2019)Microtubule-targeted drugs are essential chemotherapeutic agents for various types of cancer. A series of 3-vinyl-β-lactams (2-azetidinones) were designed, synthesized and evaluated as potential tubulin polymerization ... -
4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2
(2023)Annexin A1 is a key anti-inflammatory effector protein that is involved in the anti-inflammatory effects of glucocorticoids. 4-Octyl itaconate (4-OI), a derivative of the endogenous metabolite itaconate, which is abundantly ... -
4-octyl itaconate and itaconate in the regulation of type I interferon in macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Itaconate is an endogenous immunomodulatory metabolite produced by the enzyme aconitate decarboxylase 1 (ACOD1), a product of the gene immune-responsive gene 1 (Irg1). Itaconate is the most highly upregulated metabolite ... -
4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1
(2023)In recent years, especially since the outbreak of the severe acute respiratory syndrome coronavirus 2 pandemic, the cell-permeable itaconate derivative 4-octyl itaconate (4-OI) has gained traction as a potential antiviral ... -
5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice
(2018)In vertebrates, the initial step in heme biosynthesis is the production of 5-aminolevulinic acid (ALA) by ALA synthase (ALAS). ALA formation is believed to be the rate-limiting step for cellular heme production. Recently, ... -
A biochemical oscillator : experimental and theoretical studies of the peroxidase-oxidase reaction
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2000)The peroxidase-oxidase (PO) reaction is the haem-peroxidase catalysed reaction of molecular oxygen with NADH, and has been shown previously to behave in an oscillatory fashion. It has been used here as a useful laboratory ... -
A comparative genomics analysis of the vertebrate immune system : genes, pathways and evolution
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)All species possess a selection-honed collection of genes whose products function in unison to form a barricade to invading pathogens. The exponential increase in publicly available sequence data has allowed the application ... -
A role for eIF4A1 in IL-10 induction by LPS
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)microRNAs are a family of short non-coding RNAs that act as fine tuners of gene expression by controlling mRNAs. They have been implicated in numerous diseases including inflammatory diseases. A number of studies have ... -
A role for microRNA-21 in the regulation of gastrointestinal health and disease
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)The gastrointestinal (GI) tract is a crucial site of innate and adaptive immune regulation, balancing tolerance of beneficial commensal microorganisms and reaction to invading pathgens. Pattern recognition receptors (PRRs), ... -
A role for type 111 interferons in the natural killer cell immune response to virus
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Natural Killer (NK) cells are fundamental effector cells of the innate immune system that function to eliminate virally infected and transformed cells. One key way in which they do this is through the production of cytokines, ... -
A structural study of ALgE, transporter of alginate from Pseudomonas aeruginosa PAOI
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Pseudomonas aeruginosa is an opportunistic human pathogen that causes serious diseases in humans with immune system deficiencies, such as cystic fibrosis, wound infections, urinary tract infections, and blood stream ... -
A study of the effects of neurotoxins on the activity and copper of Ceruloplasmin
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)This thesis focuses on the ability of neurotoxins to affect the activity of the copper transport protein ceruloplasmin (EC 1.16.3.1; ferroxidase) and its intrinsic oxidase activities. The protective properties of taurine ... -
A study of the glycosylphosphatidylinositol phospholipase C in Trypanosoma brucei
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Trypanosoma brucei represents a clade of flagellated parasites that cause human and animal trypanosomiases in sub-Saharan Africa. The glycosylphosphatidylinositol phospholipase C (GPI-PLC) is an endogenous enzyme that has ... -
A study of the multiple functions and interactions of semicarbazide sensitive amine oxidase
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)This thesis focuses on three of the recognised multiple functions of mammalian semicarbazide sensitive amine oxid ase (SSAO) and the contribution of monoamine oxidase (MAO) to some of these. SSAO is a vascular-adhesion ... -
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
(2000)Poxviruses employ many strategies to evade and neutralize the host immune response. In this study, we have identified two vaccinia virus ORFs, termed A46R and A52R, that share amino acid sequence similarity with the Toll/IL-1 ... -
Absence of Mitochondrial Uncoupling Protein 1 Affects Apoptosis in Thymocytes, Thymocyte/T-Cell profile and Peripheral T-Cell Number
(Elsevier, 2010)Our laboratory has previously demonstrated the presence of constitutively expressed mitochondrial uncoupling protein 1 in mouse thymocytes. In our endeavours to understand the role of mitochondrial uncoupling protein 1 in ... -
Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
(2011)Mitochondrial uncoupling protein 3 (UCP3) is consituitively expressed in mitochondria from thymus and spleen of mice, and confocal microscopy has been used to visualize UCP3 in situ in mouse thymocytes. UCP3 is present ...
