Biochemistry: Recent submissions
Now showing items 321-340 of 1067
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SOCS3 regulation by microRNAs, cytokines and HCV
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is the principal signalling mechanism for a wide array of cytokines. Dysregulation of JAK-STAT pathway has been noted in cancer and chronic ... -
The role of metabolism, hypoxia and immunomodulatory therapy in regulating the human Treg:Th17 cell axis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Th17 cells are important pathogenic effector cells in autoimmune diseases such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). On the other hand, regulatory T (Treg) cells play a crucial role in ... -
An investigation into the role and regulation of uncoupling protein 1 (UCP 1)
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)The use of the uncoupling protein inhibitor GDP was used to investigate UCP 1 dependent ROS production in BAT and thymus mitochondria. The effect of UCP 1 inhibition by GDP was then corroborated using UCP 1 ablated mice ... -
Towards an improved understanding of local uterine innate immunity and histological change in postpartum cows : relevance to fertility?
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Uterine involution in postpartum (pp) cows is necessary for establishment of the next pregnancy. Endometritis perturbs involution, impairs uterine function and causes systemic illness leading to significant involuntary cow ... -
Natural Killer cells integrate signals received from tumour interactions and IL2 to induce robust and prolonged anti-tumour and metabolic responses
(2019)Natural Killer (NK) cells are lymphocytes with an important role in anti-tumour responses. NK cells bridge the innate and adaptive arms of the immune system; they are primed for immediate anti-tumour function but can also ... -
Immunization with whole cell but not acellular pertussis vaccines primes CD4 T <inf>RM</inf> cells that sustain protective immunity against nasal colonization with Bordetella pertussis
(2019)Protective immunity wanes rapidly after immunization of children with acellular pertussis (aP) vaccines and these vaccines do not prevent nasal colonization or transmission of Bordetella pertussis in baboons. In this study, ... -
Mitochondrial physiology.
(2020)As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. ... -
PDK1 regulation of mTOR and Hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
(2012)mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8+ cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the ... -
Next-generation anti�Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?
(2019)Disease severity in patients with atopic dermatitis (AD) isdirectly correlated with colonization by Staphylococcus aureus.1 An increasing body of evidence now also supports a role for Saureusin the pathogenesis of AD in ... -
Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target
(2019)Staphylococcus aureus expresses a number of cell wall-anchored proteins that mediate adhesion and invasion of host cells and tissues and promote immune evasion, consequently contributing to the virulence of this organism. ... -
Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?
(2019)Staphylococcus aureus bloodstream infection can have potentially catastrophic consequences for patients on hemodialysis. Consequently, an effective vaccine to prevent S aureus infection would have a significant influence ... -
IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.
(2017)IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. Staphylococcus aureus has previously been shown ... -
Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms
(2018)Systemic inflammation can impair cognition with relevance to dementia, delirium and post-operative cognitive dysfunction. Episodes of delirium also contribute to rates of long-term cognitive decline, implying that these ... -
Chronic neurodegeneration induces Type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
(2019)Type I interferons (IFN‐I) are the principal antiviral molecules of the innate immune system and can be made by most cell types, including central nervous system cells. IFN‐I has been implicated in neuroinflammation during ... -
Thinking outside the NR box : advancing novel non ligand binding pocket antagonists for the human androgen receptor
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Current treatment of prostate cancer (PCa) typically involves administration of 'classical' antiandrogens, competitive inhibitors of natural androgen receptor (AR) ligands, dihydrotestosterone (DHT) and testosterone (tes), ... -
Studies on the relationship between metabolism and control of N-linked Glycosylation in CHO cells
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)The process of post-translational attachment of oligosaccharide structures to asparagine residues in nascent polypeptides is termed N-linked glycosylation. These glycan structures can influence the folding, stability, ... -
Development of novel pyrrolo-1,5-benzoxazepines as anti-cancer agents for the treatment of chronic myeloid leukaemia
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Chronic myeloid leukaemia (CML) is characterised by the presence of a constitutively active tyrosine kinase known as Bcr-Abl. The Bcr-Abl kinase inhibitor, STI571, is the first line treatment for CML, but the recent emergence ... -
Identification of the mammalian queuine transfer RNA ribosyltransferase complex and characterisation of QTRT1 gene-trap mice deficient in queuosine modified transfer RNA
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Queuine, or Q-base, is a modified form of 7-deazaguanine that is synthesised de novo by eubacteria, but which is obtained from food or the gut flora by eukaryotes. Q-base is enzymatically inserted into the wobble position ... -
An investigation into the physiological expression and function of mitochondrial uncoupling protein 1 in thymus
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)Our study confirms the presence of mitochondrial uncoupling protein 1 in thymus. Using laser scanning confocal microscopy, we showed the constitutive expression of UCP 1 in pure thymocytes. Using a primary peptide antibody ... -
A mechanism for bistability in glycosylation
(2018)Glycosyltransferases are a class of enzymes that catalyse the posttranslational modification of proteins to produce a large number of glycoconjugate acceptors from a limited number of nucleotide-sugar donors. The products ...
