Biochemistry: Recent submissions
Now showing items 361-380 of 1067
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NK1.1 receptor ligation or tumour interactions prime NK cells for IL2-mediated metabolic and functional responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Natural Killer (NK) cells undergo a distinct metabolic response following cytokine stimulation, which involves increased rates of glycolysis and oxidative phosphorylation (OxPhos). This metabolic response is essential for ... -
Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.
(2018)CD141+ DC are implicated in antiviral and antitumor immunity. However, mechanisticstudies in autoimmune disease are limited. This is the first study to our knowledgeexamining CD141+ DC in autoimmune disease, specifically ... -
Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis.
(2018)Rheumatoid arthritis is characterized by synovial proliferation, neovascularization and leucocyte extravasation leading to joint destruction and functional disability. The blood vessels in the inflamed synovium are highly ... -
Plant-derived polyphenols modulate human dendritic cell metabolism and immune function via AMPK-dependent induction of heme oxygenase-1
(2019-03-01)Polyphenols are important immunonutrients which have been investigated in the context of inflammatory and autoimmune disease due to their significant immunosuppressive properties. However, the mechanism of action of many ... -
Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis
(2019)In this study we examined the metabolic requirements of human T helper cells and the effect of manipulating metabolic pathways in Th17 and Treg cells. The Th17:Treg cell axis is dysregulated in a number of autoimmune or ... -
Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking
(2019)The Rab family of small GTPases regulate various aspects of cellular dynamics in eukaryotic cells. Membrane trafficking has emerged as central to the functions of leucine-rich repeat kinase 2 (LRRK2), which is associated ... -
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation: Contributions of Src- and receptor-tyrosine kinases
(American Society for Biochemistry and Molecular Biology, 2005)The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine signal transduction. SOCS3 is a key negative regulator of interleuking-6 (IL-6) signal transduction. Furthermore, SOCS3 was shown ... -
3-Vinylazetidin-2-Ones: Synthesis, antiproliferative and tubulin destabilizing activity in MCF-7 and MDA-MB-231 Breast Cancer Cells
(MDPI, 2019)Microtubule-targeted drugs are essential chemotherapeutic agents for various types of cancer. A series of 3-vinyl-β-lactams (2-azetidinones) were designed, synthesized and evaluated as potential tubulin polymerization ... -
Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation
(2011)Dendritic cells (DCs) are likely to play a key rolein the compromised T-cell function associated with hepatitis C Virus (HCV) infection. However, studies of DC function inHCV-infected patients to date have yielded conflicting ... -
Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection
(2010)CD209, a c-type lectin expressed by dendritic cells (DCs), acts as a pathogen recognition receptor. A single nucleotidepolymorphism (SNP) in the promoter region of CD209(-336A/G;rs4804803) affects transcription and is ... -
CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression
(Wiley, 2009)The chemokine eotaxin/CCL11 is an important mediator of leukocyte migration, but its effect on inflammatory cytokine signaling has not been explored. In this study, we find that CCL11induces suppressor of cytokine signaling ... -
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility
(Nature Research, 2011)Deubiquitinating enzymes are now emerging as potential therapeutic targets that control many cellular processes, but few have been demonstrated to control cell motility. Here, we show that ubiquitin-specific ... -
Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase
(2007)Respiratory syncytial virus (RSV) infection causes bronchiolitis and pneumonia in infants. RSV has a linear single-stranded RNA genome encoding 11 proteins, 2 of which are nonstructural (NS1 and NS2). RSV specifically down ... -
The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression
(2004)Suppressors of cytokine signaling (SOCS) are encoded by immediate early genes known to inhibit cytokine responses in a classical feedback loop. SOCS gene expression has been shown to be induced by many cytokines, ... -
MicroRNA: master controllers of intracellular signaling pathways.
(Springer, 2015)Signaling pathways are essential intracellular networks that coordinate molecular outcomes to external stimuli. Tight regulation of these pathways is essential to ensure an appropriate response. MicroRNA (miRNA) is ... -
Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway.
(Springer, 2017)Interferon-alpha (IFN-a) is a potent anti-viral cytokine, critical to the host immune response against viruses. IFN-a is first produced upon viral detection by pathogen recognition receptors. Following its expression, IFN-a ... -
SOCS3 revisited: a broad regulator of disease, ready for therapeutic use?
(Springer, 2016-03-24)Since their discovery, SOCS have been characterised as regulatory cornerstones of intracellular signalling. While classically controlling the JAK/STAT pathway, their inhibitory effects are documented across several ... -
The role of amines in paraganglioma, neuroblastoma and carcinoid diagnosis
(Trinity College (Dublin, Ireland). Department of Chemical Pathology, 2000)The role of urinary noradrenaline, adrenaline, dopamine, 4-hydroxy-3-methoxy-mandelic acid (HMMA) and homovanillic acid (HVA) in the diagnosis of paraganglioma especially phaeochromocytoma and in neuroblastoma is investigated. ... -
Structure-function and pharmacological studies on the mammalian serotonin transporter
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2002)In Pichia pastoris, the existing membrane ergosterol was replaced by cholesterol in an attempt to improve folding of the low affinity heterologously expressed rat serotonin transporter, as judged by means of radioligand ... -
The alcohol dehydrogenases of Bacillus stearothermophilus
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2001)A 1.5-kb fragment of Bacillus stearothermophilus DSM 2334 DNA was subcloned into pUC18, and the nucleotide sequence was determined. The fragment contained a complete open reading frame that encoded a 339-residue amino-acid ...
