Biochemistry: Recent submissions
Now showing items 501-520 of 1067
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The novel immuno-regulatory effects of the Hepatitis C Virus (HCV) protein p7
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Hepatitis C virus (HCV) is a significant global pathogen and a leading cause of liver disease. HCV is highly effective at establishing a chronic infection, however its acute infection is often asymptomatic, for reasons ... -
Investigating the role of cell wall-anchored proteins during Staphylococcus aureus skin infection and as vaccine antigens
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Staphylococcus aureus has become increasingly resistant to antibiotics and community acquired methicillin resistant S. aureus (CA-MRSA) skin and soft tissue infections (SSTIs) are occurring with increasing frequency in ... -
Molecular investigation of mitophagy in neuronal cell models
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Autophagy functions as a cellular recycling and quality control pathway and is likely responsible for maintenance of viable mitochondria by mitophagy, even though exact mechanisms remain unclear. Mitophagy is characterised ... -
TLR9 Turns the Tide on Treg Cells
(2008) -
Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
(2017)STING is an innate immune cytosolic adaptor for DNA sensors that engage malaria parasite ( Plasmodium falciparum ) or other pathogen DNA. As P. falciparum infects red blood cells and not leukocytes, how parasite DNA ... -
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
(2017)The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting strain. Reactive oxygen species are ancient processes that ... -
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity
(2017)Glutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-inflammatory role in response to LPS. Here we show that genetic knockout of Gsto1 alters the response of mice to three distinct ...
