dc.contributor.author | Mc Lysaght, Aoife | en |
dc.contributor.author | Hokamp, Karsten | en |
dc.date.accessioned | 2011-08-16T14:43:24Z | |
dc.date.available | 2011-08-16T14:43:24Z | |
dc.date.issued | 2009 | en |
dc.date.submitted | 2009 | en |
dc.identifier.citation | Makino, T, Hokamp, K, McLysaght, A, The complex relationship of gene duplication and essentiality., Trends in genetics, 25, 4, 2009, 152 - 155 | en |
dc.identifier.issn | 0168-9525 | en |
dc.identifier.other | Y | en |
dc.description | PUBLISHED | en |
dc.description.abstract | In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes. | en |
dc.description.sponsorship | We would like to thank Yoichiro Nakatani for supplying lists of the WGD
duplicated genes and all the members of the McLysaght laboratory for
helpful discussions. This work is supported by Science Foundation
Ireland. | en |
dc.format.extent | 152 | en |
dc.format.extent | 155 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Trends in genetics | en |
dc.relation.ispartofseries | 25 | en |
dc.relation.ispartofseries | 4 | en |
dc.rights | Y | en |
dc.subject | Genetics | en |
dc.subject | singleton gene | en |
dc.title | The complex relationship of gene duplication and essentiality. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mclysaga | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/kahokamp | en |
dc.identifier.rssinternalid | 56268 | en |
dc.identifier.doi | http://dx.doi.org/10.1016/j.tig.2009.03.001 | en |
dc.subject.TCDTheme | Genes & Society | en |
dc.identifier.rssuri | http://dx.doi.org/10.1016/j.tig.2009.03.001 | en |
dc.identifier.orcid_id | 0000-0003-2552-6220 | en |
dc.identifier.uri | http://hdl.handle.net/2262/58715 | |