dc.contributor.author | BRADLEY, DANIEL GERARD MARY | |
dc.date.accessioned | 2013-07-09T11:36:35Z | |
dc.date.available | 2013-07-09T11:36:35Z | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012 | en |
dc.identifier.citation | Purfield, D.C., Berry, D.P., McParland, S., Bradley, D.G., Runs of homozygosity and population history in cattle, BMC Genetics, 13, 2012, art. no. 70 | en |
dc.identifier.other | Y | |
dc.description | PUBLISHED | en |
dc.description.abstract | Background: Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that are present in an individual due to parents transmitting identical haplotypes to their offspring. The extent and frequency of ROHs may inform on the ancestry of an individual and its population. Here we use high density (n = 777,962) bi-allelic SNPs in a range of cattle breed samples to correlate ROH with the pedigree-based inbreeding coefficients and to validate subsequent analyses using 54,001 SNP genotypes. This study provides a first testing of the inference drawn from ROH through comparison with estimates of inbreeding from calculations based on the detailed pedigree data available for several breeds.Results: All animals genotyped on the HD panel displayed at least one ROH that was between 1-5 Mb in length with certain regions of the genome more likely to be involved in a ROH than others. Strong correlations (r = 0.75, p < 0.0001) existed between the pedigree-based inbreeding coefficient and a statistic based on sum of ROH of length > 0.5 KB and suggests that in the absence of an animal's pedigree data, the extent of a genome under ROH may be used to infer aspects of recent population history even from relatively few samples.Conclusions: Our findings suggest that ROH are frequent across all breeds but differing patterns of ROH length and burden illustrate variations in breed origins and recent management. | en |
dc.description.sponsorship | This work was supported by Science Foundation Ireland principal
investigator award grant number 09/IN.1/B2642. We are grateful to those
researchers who have made SNP50 genotypes used in this work publicly
available. We are also grateful to the Irish Cattle Breeding Federation for
access to the pedigree data. | en |
dc.format.extent | art. no. 70 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | BMC Genetics; | |
dc.relation.ispartofseries | 13; | |
dc.rights | Y | en |
dc.subject | article; cattle; chromosomal localization; correlation coefficient; gene frequency; genotype; heterozygosity; homozygosity; inbreeding; nonhuman; pedigree; run of homozygosity; single nucleotide polymorphism | en |
dc.subject.lcsh | article; cattle; chromosomal localization; correlation coefficient; gene frequency; genotype; heterozygosity; homozygosity; inbreeding; nonhuman; pedigree; run of homozygosity; single nucleotide polymorphism | en |
dc.title | Runs of homozygosity and population history in cattle | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/dbradley | |
dc.identifier.rssinternalid | 86799 | |
dc.identifier.uri | http://hdl.handle.net/2262/66659 | |