dc.contributor.author | KELLY, JOHN MOFFAT | en |
dc.date.accessioned | 2013-08-12T13:55:50Z | |
dc.date.available | 2013-08-12T13:55:50Z | |
dc.date.issued | 2010 | en |
dc.date.submitted | 2010 | en |
dc.identifier.citation | S. Vasudevan, J. A. Smith, M. Wojdyla, T. McCabe, N. C. Fletcher, S. J. Quinn, and J. M. Kelly, Substituted Dipyridophenazine Complexes of Cr(III): Synthesis, Enantiomeric Resolution and Binding Interactions with Calf Thymus DNA, Dalton Transactions, 39, 2010, 3990-3998 | en |
dc.identifier.other | Y | en |
dc.description | PUBLISHED | en |
dc.description.abstract | [Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and
chromatographically resolved into their constituent D and K enantiomers. The DNA-binding
interactions of each of the racemic complexes were investigated, with the results of linear dichroism,
thermal denaturation, and emission quenching studies indicative of intercalative binding to CT-DNA
with a significant electrostatic contribution. UV/Vis absorption titrations suggest strong DNA binding
by each of the racemic complexes, with the methylated analogue [Cr(phen)2(Me2dppz)]3+ exhibiting the
largest equilibrium binding constant. Emission quenching and UV-Vis titrations of the enantiomers of
[Cr(phen)2(dppz)]3+ imply similar binding affinities for the D and K isomers, although significant
differences between the circular dichroism spectra of the enantiomers in the presence of DNA connote
differences in binding orientation and/or conformation between the two. | en |
dc.description.sponsorship | SV and JAS thank IRCSET for the award of postdoctoral
fellowships. The HEA (PRLTI4/CSCB) and SFI (06/CHP036
and 07/CHEF437) are thanked for their financial support.We are
grateful to Dr Martin Feeney for recording the mass spectra. | en |
dc.format.extent | 3990-3998 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Dalton Transactions | en |
dc.relation.ispartofseries | 39 | en |
dc.rights | Y | en |
dc.subject | D and K enantiomers | en |
dc.subject.lcsh | D and K enantiomers | en |
dc.title | Substituted Dipyridophenazine Complexes of Cr(III): Synthesis, Enantiomeric Resolution and Binding Interactions with Calf Thymus DNA | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/jmkelly | en |
dc.identifier.rssinternalid | 67810 | en |
dc.identifier.uri | http://hdl.handle.net/2262/66994 | |