dc.contributor.author | FARES, MARIO ALI | |
dc.date.accessioned | 2013-09-02T11:27:52Z | |
dc.date.available | 2013-09-02T11:27:52Z | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013 | en |
dc.identifier.citation | Fares, M.A., Keane, O.M., Toft, C., Carretero-Paulet, L., Jones, G.W., The Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genes, PLoS Genetics, 9, 1, 2013, art. no. e1003176 | en |
dc.identifier.other | Y | |
dc.description | PUBLISHED | en |
dc.description.abstract | Researchers have long been enthralled with the idea that gene duplication can generate novel functions, crediting this process with great evolutionary importance. Empirical data shows that whole-genome duplications (WGDs) are more likely to be retained than small-scale duplications (SSDs), though their relative contribution to the functional fate of duplicates remains unexplored. Using the map of genetic interactions and the re-sequencing of 27 Saccharomyces cerevisiae genomes evolving for 2,200 generations we show that SSD-duplicates lead to neo-functionalization while WGD-duplicates partition ancestral functions. This conclusion is supported by: (a) SSD-duplicates establish more genetic interactions than singletons and WGD-duplicates; (b) SSD-duplicates copies share more interaction-partners than WGD-duplicates copies; (c) WGD-duplicates interaction partners are more functionally related than SSD-duplicates partners; (d) SSD-duplicates gene copies are more functionally divergent from one another, while keeping more overlapping functions, and diverge in their sub-cellular locations more than WGD-duplicates copies; and (e) SSD-duplicates complement their functions to a greater extent than WGD?duplicates. We propose a novel model that uncovers the complexity of evolution after gene duplication. | en |
dc.description.sponsorship | This study was supported by Science Foundation Ireland grants to MAF under two programs: the President of Ireland Young Researcher Award (04/YI1/
M518) and the Research Frontiers Program (10/RFP/GEN2685). The study of distribution of mutations in duplicates and their possible effects on fitne
ss was
supported by a grant from the Ministerio de Ciencia e Innovacion (BFU2009-12022) to MAF. CT is supported by a long-term postdoctoral EMBO fellowship (
EMBO
ALTF 730-2011). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript | en |
dc.format.extent | art. no. e1003176 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | PLoS Genetics; | |
dc.relation.ispartofseries | 9; | |
dc.relation.ispartofseries | 1; | |
dc.rights | Y | en |
dc.subject | Gene duplication | en |
dc.subject.lcsh | Gene duplication | en |
dc.title | The Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genes | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/faresm | |
dc.identifier.rssinternalid | 86520 | |
dc.identifier.uri | http://hdl.handle.net/2262/67295 | |