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Now showing items 1261-1280 of 13947
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Unravelling the immunomodulatory effects of viral ion channels, towards the treatment of disease
(2021)The current COVID-19 pandemic has highlighted the need for the research community to develop a better understanding of viruses, in particular their modes of infection and replicative lifecycles, to aid in the development ... -
Vaccine trials during a pandemic: potential approaches to ethical dilemmas
(2021)Ever since the emergence of the coronavirus disease 2019 (COVID-19), global public health infrastructures and systems, along with community-wide collaboration and service, have risen to an unprecedented challenge. ... -
Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7.
(2022)Type I interferons (IFNs) are critical for anti-viral responses, and also drive autoimmunity when dysregulated. Upon viral sensing, monocytes elicit a sequential cascade of IFNβ and IFNα production involving feedback ... -
Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
(2021)Pathogens are thought to use host molecular cues to control when to initiate life-cycle transitions, but these signals are mostly unknown, particularly for the parasitic disease malaria caused by Plasmodium falciparum. ... -
Detection of Viral Infections by Innate Immunity
(2021)Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate immune system as they detect conserved viral pathogen-associated molecular patterns (PAMPs). A successful host response to viral ... -
Critical Disability Studies and the Affirmative Non-Tragedy Model: Presenting a Theoretical Frame for Disability and Child Protection
(2024)The purpose of this article is to present an integrated theoretical frame for the subject matter of disability and child protection. Substantive complexities, alluded to in existing literature, surround disability in child ... -
Assessment of climate change impact on the annual maximum flood in an urban river in Dublin, Ireland
(2022)Hydrological modelling to address the problem of flood risk corresponding to climate change can play an important role in water resources management. This paper describes the potential impact of climate change on an urban ... -
Review of the ecosystem services of temperate wetlands and their valuation tools
(2022)Wetlands constitute important habitats that provide several ecosystem services (ES). Wetlands have been termed the kidneys of the world for their water purification services and contain 20–25% of total soil organic carbon. ... -
Intellectual Disability, Art and Identity: A qualitative exploration of the experiences of professional artists with intellectual disabilities
(2022)Previous research suggests that participation in the arts and/or disability arts can positively influence individuals’ affirmation, or a positive embracement, of a disability identity; however, until more recently, persons ... -
A Method for Optimal Reconstruction of Velocity Response Using Experimental Displacement and Acceleration Signals
(2007)An algorithm is developed which takes advantage of the positive characteristics of integration and differentiation operations which can produce an optimal time-domain estimate of a velocity signal when a displacement and ... -
Shameless luck egalitarians
(2023)A recurring concern about luck egalitarianism is that its implementation would make some individuals, in particular those who lack marketable talents, experience shame. This, the objection goes, undermines individuals’ ... -
Flow cytometry and fecal indicator bacteria analyses for fingerprinting microbial pollution in karst aquifer systems
(2022)Microbial pollution of aquifers is a persistent water quality problem globally which poses significant risks to public health. Karst aquifer systems are exceptionally vulnerable to pollution from fecal contamination sources ... -
Explanation, Justification, and Egalitarianism
(2021)This paper argues that the philosophy of explanation can help inform core debates in value theory. Specifically, it argues that there is a consistent parallelism between the properties of explanation and the properties of ... -
Luck Egalitarianism Without Moral Tyranny
(2022)Luck egalitarians contend that, while each person starts out with a claim to an equal quantity of advantage, she can forfeit this claim by making certain choices. The appeal of luck egalitarianism is that it seems to satisfy ... -
The lived experiences of fathers of a premature baby on a neonatal intensive care unit
(2010)Aim: The aim of this study was to explore the lived experiences of fathers of a premature baby on a Neonatal Intensive Care Unit and also to raise awareness amongst healthcare professionals in relation to the needs of ... -
The unique and special role of grandparents in the lives of families from areas of urban disadvantage
(2022)Many grandparents provide support for families and have influence over the lives of their grandchildren. There are benefits associated with being a grandparent, such as positive well-being and a feeling of fulfilment. Although ... -
Durability of treatment effects following internet-delivered cognitive behavioural therapy for depression and anxiety delivered within a routine care setting.
(2022)Objective: To investigate post-treatment relapse and remission rates 3, 6 and 9 months after completion of an acute phase of a clinician-supported internet-delivered cognitive-behavioural therapy (iCBT) for anxiety and ... -
Patterns and drivers of groundwater and stream nitrate concentrations in intensively managed agricultural catchments
(2022)The environmental loss of nitrogen in agricultural landscapes has pervasive consequences, including human health implications, eutrophication, loss of habitat biodiversity and greenhouse gas emissions. The efficacy of ... -
It�s not enough to be �participatory�, the process is just as important as the technique.
(2022)Aim: to explore the health and well-being related perceptions and experiences of school-aged children and their families, who live in areas of urban disadvantage. Objectives: To explore what ‘family’ means to school-aged ... -
Exploring intermediary practices of collaboration in university? industry innovation: A practice theory approach
(2022)The intensity of the global and distributed economy requires innovative efforts that single organizations often cannot develop alone. Collaborative innovation is traditionally studied in terms of collaborative process to ...
