| dc.contributor.author | O'NEILL, LUKE | en |
| dc.date.accessioned | 2014-11-26T15:51:45Z | |
| dc.date.available | 2014-11-26T15:51:45Z | |
| dc.date.issued | 2013 | en |
| dc.date.submitted | 2013 | en |
| dc.identifier.citation | O'Neill LA, Cardiolipin and the Nlrp3 inflammasome., Cell metabolism, 18, 5, 2013, 610-2 | en |
| dc.identifier.issn | 1550-4131 | en |
| dc.identifier.other | Y | en |
| dc.description | PUBLISHED | en |
| dc.description.abstract | The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting inflammation. | en |
| dc.format.extent | 610-2 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Cell metabolism | en |
| dc.relation.ispartofseries | 18 | en |
| dc.relation.ispartofseries | 5 | en |
| dc.rights | Y | en |
| dc.subject | Biochemistry | en |
| dc.title | Cardiolipin and the Nlrp3 inflammasome. | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/laoneill | en |
| dc.identifier.rssinternalid | 98113 | en |
| dc.identifier.doi | http://dx.doi.org/10.1016/j.cmet.2013.10.013 | en |
| dc.rights.ecaccessrights | openAccess | |
| dc.identifier.uri | http://hdl.handle.net/2262/72207 | |
