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dc.contributor.authorFinlay, Daviden
dc.date.accessioned2015-05-06T14:36:35Z
dc.date.available2015-05-06T14:36:35Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationFinlay DK, Cantrell DA, Metabolism, migration and memory in cytotoxic T cells, Nature Reviews Immunology, 11, 2, 2011, 109 - 117en
dc.identifier.otherYen
dc.descriptionPUBLISHEDen
dc.description.abstractThe transcriptional and metabolic programmes that control CD8(+) T cells are regulated by a diverse network of serine/threonine kinases. The view has been that the kinases AKT and mammalian target of rapamycin (mTOR) control T cell metabolism. Here, we challenge this paradigm and discuss an alternative role for these kinases in CD8(+) T cells, namely to control cell migration. Another emerging concept is that AMP-activated protein kinase (AMPK) family members control T cell metabolism and determine the effector versus memory fate of CD8(+) T cells. We speculate that one link between metabolism and immunological memory is provided by kinases that originally evolved to control T cell metabolism and have subsequently acquired the ability to control the expression of key transcription factors that regulate CD8(+) T cell effector function and migratory capacity.en
dc.format.extent109en
dc.format.extent117en
dc.language.isoenen
dc.relation.ispartofseriesNature Reviews Immunologyen
dc.relation.ispartofseries11en
dc.relation.ispartofseries2en
dc.rightsYen
dc.subjectCD8(+) T cellsen
dc.titleMetabolism, migration and memory in cytotoxic T cellsen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/finlayden
dc.identifier.rssinternalid75180en
dc.identifier.doihttp://dx.doi.org/10.1038/nri2888en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.orcid_id0000-0003-2716-6679en
dc.identifier.urihttp://hdl.handle.net/2262/73862


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