dc.contributor.author | Finlay, David | en |
dc.date.accessioned | 2015-05-06T14:36:35Z | |
dc.date.available | 2015-05-06T14:36:35Z | |
dc.date.issued | 2011 | en |
dc.date.submitted | 2011 | en |
dc.identifier.citation | Finlay DK, Cantrell DA, Metabolism, migration and memory in cytotoxic T cells, Nature Reviews Immunology, 11, 2, 2011, 109 - 117 | en |
dc.identifier.other | Y | en |
dc.description | PUBLISHED | en |
dc.description.abstract | The transcriptional and metabolic programmes that control CD8(+) T cells are regulated by a diverse network of serine/threonine kinases. The view has been that the kinases AKT and mammalian target of rapamycin (mTOR) control T cell metabolism. Here, we challenge this paradigm and discuss an alternative role for these kinases in CD8(+) T cells, namely to control cell migration. Another emerging concept is that AMP-activated protein kinase (AMPK) family members control T cell metabolism and determine the effector versus memory fate of CD8(+) T cells. We speculate that one link between metabolism and immunological memory is provided by kinases that originally evolved to control T cell metabolism and have subsequently acquired the ability to control the expression of key transcription factors that regulate CD8(+) T cell effector function and migratory capacity. | en |
dc.format.extent | 109 | en |
dc.format.extent | 117 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Nature Reviews Immunology | en |
dc.relation.ispartofseries | 11 | en |
dc.relation.ispartofseries | 2 | en |
dc.rights | Y | en |
dc.subject | CD8(+) T cells | en |
dc.title | Metabolism, migration and memory in cytotoxic T cells | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/finlayd | en |
dc.identifier.rssinternalid | 75180 | en |
dc.identifier.doi | http://dx.doi.org/10.1038/nri2888 | en |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.orcid_id | 0000-0003-2716-6679 | en |
dc.identifier.uri | http://hdl.handle.net/2262/73862 | |