School of Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 181-200 of 668
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Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways
(2018)Sample complexity and polydispersity presents challenges surrounding particle size measurements for nanoparticles (NPs). To ensure the delivery of high quality products to the marketplace it is imperative that this task ... -
In Situ Monitoring of Nanoparticle Formation: Antisolvent Precipitation of Azole Anti-fungal Drugs.
(2018)In this work we report the effect of stabilizer choice and concentration on nanoparticle (NP) stability over time. Three different BCS class II active pharmaceutical ingredient (APIs): itraconazole (ITR), ketoconazole ... -
Intra-articular delivery of a nanocomplex comprising salmon calcitonin, hyaluronic acid, and chitosan using an equine model of joint inflammation
(2018)Polyelectrolyte nanoparticle constructs (NPs) comprising salmon calcitonin (sCT), chitosan (CS), and hyaluronic acid (HA) were previously established as having anti-inflammatory potential when injected via the intra-articular ... -
Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease.
(2018)Degeneration of the locus coeruleus noradrenergic system is thought to play a key role in the pathogenesis of Parkinson’s disease (PD), whereas pharmacological approaches to increase noradrenaline bioavailability may ... -
Costs and outcomes of cancer care in older adults : population-based analysis
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)Cancer is a major cause of mortality worldwide. The disease disproportionately affects the older population and 60% of new cancer cases and 70% of cancer-related deaths occur in individuals aged 65 or older. Large national ... -
Prevalence, patterns and factors associated with multiple medicines use in an ageing poulation with intelletual disability in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)The provision of rational and appropriate pharmacotherapy to older people with intellectual disabilities (ID) poses significant challenges due to the complexities of conditions being treated, the increased risks of adverse ... -
Moral reasoning competencies development in community pharmacists in Ireland : a repeated measures crossover study
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Research suggests that higher levels of moral reasoning competencies increase the probability that community pharmacists will make decisions in the patient's 'best interests'. Professional ethics education incorporates the ... -
Mechanistic studies into the effect of deoxycholic acid on oesophageal cancer initiation and progression
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Oesophageal cancer is the ranked as the fifth highest cancer in terms of cancer-related deaths worldwide and has an incidence rate that is increasing by 5% annually. Survival rates for oesophageal cancer are approximately ... -
Assessment of renal function in the anaesthetised rat following injection of superparamagnetic iron oxide nanoparticles
(2017)A recent study showed that a significant fall in mean arterial pressure (MAP) occurred following intravenous injection of two novel superparamagnetic iron oxide nanoparticles (SPIONs), MF66 and OD15. To assess if this was ... -
Manganese: a new contrast agent for lung imaging?
(2012)Lung parenchyma remains one of the most difficult tissues to be imaged by means of magnetic resonance imaging (MRI). Several MRI techniques are routinely used for lung imaging. However, manganese-enhancement MRI ... -
Design and biological activity of a novel bioactive indane scaffold
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)This project is focussed on the design, synthesis and pharmacological evaluation of novel drug-hybrids which combine anti-inflammatory and anti-tumour activities to target the interface between inflammatory disease and ... -
Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles.
(2019)There is an increasing interest in exploring clinically relevant information that is present in body fluids, and extracellular vesicles (EVs) are intrinsic components of body fluids (“liquid biopsies”). In this report, we ... -
Traditional chinese medicine from aqueous extracts to therapeutic formulae
(IntechOpen, 2019)Traditional Chinese medicine (TCM) is one of the most established systems of medicine in the world. The therapeutic formulae used in TCM are frequently derived from aqueous decoctions of single plants or complex multicomponent ... -
Design, Synthesis and biochemical evaluation of novel anthracenes, ethanoanthracenes and related compounds to target Burkitt's Lymphoma
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Burkitt's lymphoma is an aggressive non-Hodgkin lymphoma occurring with high incidence in developing areas such as equatorial Africa and Papua New Guinea. Within these tropical regions of high incidence (40-50 per 10 6), ... -
An exploration of the role of community pharmacists in health promotion in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)A combination of qualitative and quantitative methodologies was used to explore the research questions from a number of different angles. A literature review was carried out to identify work which had already been published ... -
Chemistry and Biology studies on anti-inflammiatory bile acid derivatives
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Abstract The objective of the dissertation is to clarify the potency, cytotoxicity and metabolism of novel steroidal anti-inflammatory compounds in the treatment inflammatory bowel disease (IBD). Biochemical methods with ... -
Density Scaling in Ionic Glass-Former Controlled by Grotthuss Conduction
(2019)We present investigations of the charge transport in an ionic glass-former carvedilol dihydrogen phosphate (CP) at various T–P–V thermodynamic conditions in terms of density scaling concept. The studied material was found ... -
Unintended discontinuation of medication following hospitalisation: a retrospective cohort study
(BMJ Publishing Group, 2019)Objectives: Whether unintended discontinuation of common, evidence-based, long-term medication occurs after hospitalisation; what factors are associated with unintended discontinuation; and whether the presence of documentation ... -
The effect of electrostatic interactions on the formation of pharmaceutical eutectics
(2018)Over the past decade, the formation of pharmaceutical eutectics has become a very attractive strategy to increase the bioavailability of active pharmaceutical ingredients (APIs). A great advantage of a eutectic phase, which ... -
Effect of electrostatic interactions on the relaxation dynamics of pharmaceutical eutectics
(2019)In this paper, we investigate the temperature-dependent relaxation dynamics in the glassy and supercooled liquid state of dipolar and ionic eutectic mixtures made of two anesthetic agents (lidocaine and prilocaine) and ...
