School of Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 201-220 of 668
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Cardioprotective effect of MMP-2-inhibitor-NO-donor hybrid against ischaemia/reperfusion injury.
(2019)Hypoxic injury of cardiovascular system is one of the most frequent complications following ischaemia. Heart injury arises from increased degradation of contractile proteins, such as myosin light chains (MLCs) and troponin ... -
Synthesis, screening and pharmacokinetic evaluation of potential prodrugs of bupropion
(2014)In general, prodrugs are developed to circumvent deficiencies associated with the absorption, distribution, metabolism, excretion or toxicological (ADMET) profile associated with the active drug. In our study, we select ... -
Antinociceptive activity of Cistanche salsa stolons, growing in the Republic of Kazakhstan
(2017)Herba Cistanche (Cistanche species) in Traditional Chinese Medicine is used for the treatment of several diseases and symptoms, to include pain. The objective of this study was to evaluate the antinociceptive effect of the ... -
Chemical composition and enzyme inhibition of Phytolacca dioica L. seeds extracts
(Frontiers, 2019)Phytolacca, which belongs to the family of Phytolaccaceae, are known for their use in popular medicine.Bioactivity of five extracts from Phytolacca dioica seeds were evaluated in four bioassays. A selected groupof compounds ... -
Part Two: Evaluation of N-methylbupropion as a Potential Bupropion Prodrug
(2014)N-methylbupropion was selected as a potential prodrug from our in vitro screening of analogues of bupropion described in the preceding paper. This study describes in vivo pharmacokinetics of N-methylbupropion in the ... -
HPLC profiling of Mimosa pudica polyphenols and their non-invasive biophysical investigations for anti-dermatoheliotic and skin reinstating potential
(2019)Plant-derived polyphenols are known to have promising biological activities including antioxidant and anti-tyrosinase and may be a potential candidate for anti-dermatoheliotic remedy. The present study was performedto ... -
In Situ Cocrystallization of Dapsone and Caffeine during Fluidized Bed Granulation Processing
(American Association of Pharmaceutical Scientists ; Springer Verlag, 2019-01)Different pharmaceutical manufacturing processes have been demonstrated to represent feasible platforms for the production of pharmaceutical cocrystals. However, new methods are needed for the manufacture of cocrystals on ... -
Amorphous solid dispersions of ketoprofen and poly-vinyl polymers prepared via electrospraying and spray drying: A comparison of particle characteristics and performance.
(Elsevier, 2019-07-20)The purpose of this work was to compare the particle characteristics and dissolution performance of amorphous solid dispersions (ASDs) of ketoprofen and vinyl-pyrrolidone based polymers prepared using electrospraying and ... -
A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products.
(2018)The purpose of this work was to investigate the application of different advanced continuous processing techniques (hot melt extrusion and spray drying) to the production of fixed-dose combination (FDC) monolithic systems ... -
Development of a new formulation of roflumilast for pulmonary drug delivery to treat inflammatory lung conditions.
(2018-10-25)The aim of this study was to develop roflumilast dry powder inhaler (DPI) formulations by spray drying using hydroxypropyl-β-cyclodextrin (HPβCD) and to determine their suitability for pulmonary delivery. Different feed ... -
Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion.
(2018)The comparison of spray drying versus hot melt extrusion (HME) in order to formulate amorphous solid dispersions has been widely studied. However, to the best of our knowledge, the use of both techniques to form cocrystals ... -
Production of cocrystals in an excipient matrix by spray drying
(2018-01)Spray drying is a well-established scale-up technique for the production of cocrystals. However, to the best of our knowledge, the effect of introducing a third component into the feed solution during the ... -
Development and characterization of dapsone cocrystal prepared by scalable production methods
(American Association of Pharmaceutical Scientists ; Springer Verlag, 2018)In this study, the formation of caffeine:dapsone (CAF:DAP) cocrystals by scalable production methods, such as liquid assisted grinding (LAG) and spray drying, was investigated in the context of the potential use of processed ... -
Modelling and understanding powder flow properties and compactability of selected active pharmaceutical ingredients, excipients and physical mixtures from critical material properties
(2017)The development of solid dosage forms and manufacturing processes are governed by complex physical properties of the powder and the type of pharmaceutical unit operation the manufacturing processes employs. Suitable powder ... -
Comparison of wet milling and dry milling routes for ibuprofen pharmaceutical crystals and their impact on pharmaceutical and biopharmaceutical properties
(2018-05)The development of solid dosage forms and manufacturing processes are governed by complex physical properties of the powder and the type of pharmaceutical unit operation the manufacturing processes employs. Suitable powder ... -
Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating
(2018)Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the ... -
Studies into the in vitro metabolism and antiplatelet effects of novel aspirin ester prodrugs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)Aspirin is the most commonly used antiplatelet agent in the world, and is invaluable in prevention o f myocardial infarction, thrombosis and stroke. However prolonged use has been associated with gastrointestinal side-effects ... -
In vivo and in vitro mechanistic studies on targeting of lipophilic compounds to the intestinal lymphatics using lipid-based vehicles
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)The aim of the experiments conducted in this thesis was to investigate the effect of a range of lipid-based vehicles on the intestinal lymphatic transport of triglycerides and of two lipophilic compounds- DDT and cyclosporine, ... -
Preparation of cocrystal-in-excipient systems by advanced pharmaceutical methods
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis focuses on the production of cocrystal-in-excipient systems by a variety of advanced pharmaceutical methods, such as spray drying, hot melt extrusion and spray coating. The production of cocrystal-in-excipient ... -
The production, characterisation, stabilization and isolation of azole anti-fungal nanoparticles
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)In this work, the effect of stabilizer choice and concentration was investigated on nanoparticle (NP) stability over time. Three different BCS class II active pharmaceutical ingredients (APIs): itraconazole (ITR), ketoconazole ...
