School of Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 341-360 of 668
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MicroRNA Profiling of Exosomes
(Springer, 2017) -
Modelling and shadowgraph imaging of cocrystal dissolution and assessment of in vitro antimicrobial activity for sulfadimidine/4-aminosalicylic acid cocrystals
(2016)Purpose: The aim of this work was to evaluate the influence of crystal habit on the dissolution and in vitro antibacterial and anitiprotozoal activity of sulfadimidine:4-aminosalicylic acid cocrystals. Methods: Cocrystals ... -
Impact of substrate properties on the formation of spherulitic films: a case study of salbutamol sulfate
(2016)Spherulitic assemblies have applications as carriers for drug delivery and as targeting vectors. Presently, the driving force behind the formation of spherulites comprising small drug molecules is not fully understood. ... -
Cocrystal habit engineering to improve drug dissolution and alter derived powder properties
(2016)Objectives: Cocrystallization of sulfadimidine (SDM) with suitable coformers, such as 4-aminosalicylic acid (4-ASA), combined with changes in the crystal habit can favourably alter its physicochemical properties. The aim ... -
Emerging nanonisation technologies: tailoring crystalline versus amorphous nanomaterials
(2015)The overall pharmaceutical market is changing. A more personalised medicine approach is replacing the concept of blockbuster drugs and the “one size fits all” model. The two main forces that fuel the growth of nano-enabled ... -
Development of a novel dry powder inhalation formulation for the delivery of rivastigmine hydrogen tartrate
(2016)he purpose of this study was to prepare engineered particles of rivastigmine hydrogen tartrate (RHT) and to characterize the physicochemical and aerodynamic properties, in comparison to a lactose carrier formulation (LCF). ... -
Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation
(2016)In the present study, in vitro permeation experiments in a Franz diffusion cell were performed using different synthetic polymeric membranes and pig ear skin to evaluate a rivastigmine (RV) transdermal drug delivery system. ... -
Mitigating unwanted amorphisation: A screening method for the selection of suitable excipients
(2016)Co-processing an active pharmaceutical ingredient (API) with a low Tg excipient has been previously reported to be an effective strategy for preventing drug amorphisation on milling. This technique relies on the ability ... -
Novel Selective Butyrylcholinesterase Inhibitors Incorporating Antioxidant Functionalities as Potential Bimodal Therapeutics for Alzheimer's Disease
(2016)sosorbide-2-carbamates-5-aryl esters are highly potent and very selective butyrylcholinesterase inhibitors. The objective of the present work was to address the hypothesis that the isosorbide-aryl-5-ester group could be ... -
A Central Role for Monocyte-Platelet Interactions in Heart Failure
(2015)Heart failure (HF) is an increasingly prevalent and costly multifactorial syndrome with high morbidity and mortality rates. The exact pathophysiological mechanisms leading to the development of HF are not completely ... -
The synthesis of novel mast cell stabilisers from benzocycloalkanones
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)The purpose of this project was to design and synthesise novel classes of mast cell stabilisers from benzocycloalkanones. This thesis is introduced with an overview of the increasing prevalence of allergic conditions ... -
Investigations into the anti allergy properties of novel benzocycloalkanone based compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)An allergic response occurs because of a hypersensitive response by mast cells to an otherwise innocuous environmental substance. Allergen challenge causes mast cell degranulation, resulting in the release of mast cell ... -
Stability and hydrolysis studies of novel dual acting conjugate drugs with anitcancer activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)Tamoxifen is currently a first-line endocrine therapy for the adjuvant treatment of Estrogen Receptor (ER) positive breast cancer. The antiestrogenic properties of this compound are related to its ability to compete for ...
