School of Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 361-380 of 668
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Endothelium as a target in the design of novel tumour antiangiogenic / vasculature-targeting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)This thesis begins with a review of tumour growth and development, with a particular focus on angiogenesis. The numerous mechanisms which regulate the process are touched upon, with current and fiiture antiangiogenic agents ... -
The design, synthesis and biological evaluation of novel barbiturate-based MMP inhibitors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Matrix metalloproteinases (MMPs) are a group of Zn-dependent endopeptidases that participate in many diseases. Two MMPs, MMP-2 and MMP-9, which are especially associated with inflammatory diseases and tumor metastasis have ... -
Investigations of beta-lactams as novel bioactive compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)A natural stilbene product combretastatin A-4 (CA-4) is a known anti-cancer compound, which exerts its mechanism of action at the colchicine binding site on tubulin, a protein that is essential for the replication of cells. ... -
Chemical and morphological variability of Taxus : needles, seeds and cell cultures
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)The genus Taxus (family Taxaceae) has during the last 30-40 years been the subject of extensive scientific investigation due to the discovery of the anti-cancer drug paclitaxel (Taxol) originally isolated from the bark of ... -
Formulation and characterisation of polyelectrolyte complex nanoparticles for the delivery of salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis explored the formulation of various polyelectrolyte complex nanoparticles as potential carriers for the delivery of macromolecules. The complexes were formed between a polyanion (hyaluroninc acid, ... -
Caffeine exacerbates the toxicity of 3,4 methylenedioxymethamphetamine (MDMA, Ecstasy ) : a role for dopamine
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Co-administration of caffeine profoundly enhances the acute toxicity of the substituted amphetamine 3, 4-methylenedioxymethamphetamine (MDMA “Ecstasy”) in rats, evidenced by high body temperature, tachycardia and increased ... -
Investigations of physicochemical properties of spray dried drug-excipient composites directed to inhalable products
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)The studies in this thesis explored the solid state and inhalation properties of various systems produced by the spray drying technique. The work focused on the feasibility analysis of spray drying as a means of producing ... -
Liposomes as carriers for systemic delivery of salmon calcitonin by inhalation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The concept of delivering proteins and peptides to the systemic circulation via the lungs has been extensively investigated over the last 20 years. Main drivers for the approach are the lungs’ high surface area, presumed ... -
A pharmacokinetic and clinical evaluation of antimicrobial drugs in critically ill patients during Continuous Venovenous Haemodifiltration (CVVHDF) therapy
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)Critically ill patients are at risk from sepsis requiring antimicrobial therapy and acute renal failure, which may require extracorporeal renal replacement therapy. The objective of this study was to quantify and assess ... -
Flexible estrogen receptor modulators
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Tamoxifen is a selective estrogen receptor modulator (SERM) with a triarylethylene structure, which has estrogenic activity in bone and endometrial tissue, yet antagonises the actions of estrogen in other tissues including ... -
Characterisation and analysis of beta-aminoketones as potential prodrugs for amines
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)The aim of the work described in this thesis is to evaluate the potential of β-aminoketones as amine prodrugs. These compounds are usually stable in acidic conditions while they cleave into the parent amine and an ... -
Design and synthesis of 4-[1,3-diaryl-1H-pyrazole-4-yl]-2,6-dimethyl-1,4-dihydropyridine compounds and evaluation as anti-proliferative and multi-drug resistance reversal agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)1,4-Dihydropyridines are well known for their use as calcium channel blockers and are extensively used in treatment of hypertension. Dihydropyridine derivatives such as nifedipine have been shown to have the potential to ... -
Investigation into bile acid effects on the golgi apparatus, cell viability and glucocorticoid receptor distribution in esophageal cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Bile acids are a family of steroidal molecules derived from cholesterol and biosynthesised in the pericentral hepatocytes in the liver. In recent years there has been a renaissance in bile acid based research as it has ... -
The design and synthesis of novel inhibitors of tubulin polymerisation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This thesis is introduced with a review on the principles of tubulin polymerisation and how this process is necessary for cellular replication. This leads on to discussion of the structure-activity relationships of known ... -
The use of the Caco-2 cell culture model to investigate lipid vehicle effects on lipid metabolism and drug permeation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)The aim of this thesis was to assess the usefulness of the Caco-2 model for screening lipid vehicle excipient effects on intestinal lipoprotein production and secretion, with emphasis on chylomicron secretion. In addition, ... -
Functional expression of the epithelial sodium channel δ-subunit in human respiratory epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Mammalian amiloride-sensitive epithelial Na+ channel (ENaC) can be composed by different combinations of four homologous subunits, α, β, γ and δ. The canonical αβγ- ENaC, abundantly expressed in Na+ absorbing epithelia, ... -
A novel method for the measurement of flow-induced platelet activation at nanoscale resolution level
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Background: Platelet aggregation Is essential for vascular haemostasis and thrombosis. Inhibition of platelet aggregation underpins the pharmacological and clinical effects of antiplatelet drugs. These effects are commonly ... -
Drug transport across the human respiratory epithelial barrier
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Drug transporters have only recently moved into the centre of attention of pulmonary drug delivery research, and of the more than 400 identified transporter proteins, only little information is available. In a first step, ... -
Use of halloysite for agrochemical applications
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)The focus of this thesis was to develop two products for use in agrochemical applications, using the naturally occurring microtubular mineral, halloysite. Firstly, it was necessary to obtain a highly tubular grade of the ... -
Potential applications of halloysite for improved topical drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The aim of this thesis was to evaluate the potential application of halloysite, an aluminosilicate clay material, for use in topical and transdermal drug delivery. Halloysite is a tubular material, the hollow lumen has ...
