School of Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 421-440 of 668
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Mechanistics aspects of the release of drugs from hydrophilic polymer matrices
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)Hydrophilic polymers, which both swell and erode, are widely used to produce sustained release of drugs from monolithic matrices, and have been extensively reviewed in the literature (Alderman 1984), (Peppas and Korsmeyer ... -
An investigation into the effects of current immunosuppressants and novel compounds on animal models of asthma and delayed type hypersensitivity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)Asthma is a disease with a worldwide distribution and of increasing prevalence. There are two forms of the disease; intrinsic, which is believed to follow a Th1 cytokine profile and extrinsic, which follows a Th2 response. ... -
Design, synthesis and in vitro evaluation of novel anti-cancer compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The purpose of this thesis was the design, synthesis and in vitro appraisal of a novel class of ITP/APN dual inhibitory compounds. Additionally, a class of novel biaryls, which were synthesised within the research group, ... -
The pharmacological and toxicological effects of polystyrene and silica nanoparticles on human airway epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Background and purpose: A number of lung pathologies are associated with the dysfunction of ion flux through pulmonary epithelium. Cystic fibrosis (CF) is a chronic and life-threatening genetic disease that directly affects ... -
The design, synthesis and biological effects of novel steroid prodrugs for treatment of gastrointestinal diseases
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)The aim of the work described in this thesis was to synthesize and test the biological effects of a novel type of prodrug to deliver steroids to the colon for the treatment of gastrointestinal diseases. Glucocorticoids are ... -
Synthetic, photophysical and biological studies into new tools for investigating bile acid disposition and toxicity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The overall objective of this thesis was to use synthetic chemistry to provide tools to understand problems in bile acid research including their disposition and mechanism of toxicity. Fluorescent reporter groups are very ... -
The design, synthesis and biochemical evaluation of novel flexible and conformationally restrained antiestrogens
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)This thesis is presented in four different sections. In the first section the synthesis of a number of structural (novel flexible) analogues of the antiestrogen drug tamoxifen is described. Preparation of novel conformationally ... -
Design, synthesis and evaluation of novel tumour vasculature-targeting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)This thesis is introduced with a review of the 'Hallmarks of Cancer', outlining each one as a potential target for drug therapy. Vascular targeting as a means of cancer growth retardation is specifically discussed. The ... -
Design, synthesis and biochemical evaluation of novel 1,2,3,4-tetrahydroisoquinolines as anti-proliferative agents in breast cancer cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Isoquinolines are naturally occurring alkaloids that have shown biological activity in a number of different areas. In terms of breast cancer, tetrahydroisoquinoline based compounds have shown potential as selective estrogen ... -
Intestinal lymphatic transport of DDT and Saquinavir : the role of lipid based formulations and modulators of P-Glycoprotein and Cytochrome P450
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)The experiments in this thesis represent biopharmaceutical investigations, performed in an attempt to evaluate potential dosage form strategies designed to promote the intestinal lymphatic transport of lipophilic compounds. ... -
Pharmaceutical cocrystals : a contribution to fundamental studies addressing solubility, dissolution, formation and characterisation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)This thesis has focused on the study of pharmaceutical cocrystals. The investigations have addressed the solubility, dissolution and stability of cocrystals as well as the evaluation of selected production techniques, in ... -
The design, synthesis, and evaluation of the Azetidin-2-one ring as a scaffold for novel combretastatin A4 analogues
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Combretastatin A-4 (CA4) is a natural product first isolated from the Combretum caffrum South African willow tree by Pettit and co-workers. CA4 has proved to be a potent antimitotic agent, with a mechanism of action ... -
Influence of anti-inflammatory interventions in the Kainic acid model of hippocampal excitotoxicity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Excitotoxicity is implicated as a mechanism of neuronal cell death in a range of neurodegenerative disorders. Such toxicity can be induced experimentally by systemic administration of the glutamate kainate receptor agonist, ... -
Investigation of ibuprofen release from ethylcellulose matrix compacts
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)A comprehensive study of ethylcellulose powder and ethylcellulose compacts (of different ethylcellulose viscosity grades) was undertaken. Studies showed that the lower viscosity grade ethylcellulose (4 cP) was more ... -
Neuronal Nitric oxide synthase : a novel target for antidepressant activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Major depressive disorder (MDD) is one of the most common psychiatric disorders and its origin has been attributed to dysfunction of the monoamine systems, particularly noradrenergic and serotonergic, making them the main ... -
Production and characterisation of spray dried particulate systems for pulmonary drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The work presented in this thesis concerns the application of a particle engineering technology, one-step spray drying method, to produce porous particles of antitubercular drugs, suitable for inhalation and to study the ... -
Blood biocompatiblity of polyvinyl, chloride surface-modified with multi-walled carbon nanotubes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Blood-surface interaction in extracorporeal circuits (for example, cardiopulmonary bypass) requires the infusion of a systemic anticoagulant to prevent devastating thrombus formation. Platelet activation upon contact with ... -
Studies on the design, synthesis and stability of novel anti-allergy agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The purpose of this project was to design and synthesise novel classes of anti-allergy compounds using 1-tetralone as the principal building block. This thesis is introduced with an overview of the prominent role played ... -
Characterisation of drug transporters in human respiratory epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Cell culture models are an efficient and relatively cheap tool to study isolated mechanisms of an organ. The right cell model, carefully selected to allow highest benefits, can give valuable information in the area of ... -
Identification of novel targets for cancer chemotherapeutic agents : design, synthesis and evaluation of chromene based compounds with affinity for steroid hormone receptors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Breast cancer is the second most common cancer in Ireland and accounts for 28% of all cancers in women in Ireland, with an average of 1726 new diagnosis each year. One of the major therapeutic advances in clinical treatment ...
