School of Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 401-420 of 668
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Studies in the synthesis and in vitro hydrolysis of novel aspirin prodrugs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)Prolonged aspirin use has been associated with an increased risk of gastrointestinal bleeding, leading in some instances to haemorrhage and death. This thesis describes the design of aspirin prodrugs, from which aspirin ... -
A study of the release of the amphoteric drug amoxycillin from biodegradable polymers
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Poly-alpha-hydroxy-aliphatic esters constitute a group of biodegradable polymers which have been actively investigated over the past three decades for the sustained release of drug compounds. A literature review revealed ... -
Characterisation of polymorphisms on the promoter region of the human histamine 4 receptor
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The human histamine 4 receptor (HRH4) is the recently discovered receptor in the histamine GPCR family. It is mainly expressed in haematopoietic cells but recent publications provide evidence that it is both expressed and ... -
Design, synthesis and biochemical evaluation of novel antiproliferative agents for the treatement of Burkitt's Lymphoma
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)This thesis is concerned with the identification of novel antiproliferative agents for the treatment of Burkitt's lymphoma (BL), an aggressive B-cell malignancy. Numerous SERT and NET ligand such as SSRIs and TCAs, having ... -
The development, validation and application of analytical methods for the analysis of drugs of abuse
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)There are five chapters presented in this thesis. The first chapter deals with development and validation of a HPLC method for the analysis of MDMA in illicitly produced Ecstasy tablets. In all 100 tablets were analysed ... -
Transdermal delivery of somatostatin analogues
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)The aim of this work was to develop transdermal delivery systems for the administration of two peptidic somatostatin analogues, BIM-23014 and its higher potency analogue BIM-23190. Due to its ability to suppress growth ... -
Formulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The current study involved the preparation of a range of micro and nano particulates from known biocompatible pharmaceutical polymeric excipients: PLGA, chitosan and hyaluronic acid, using physical rather than chemical ... -
Investigation of factors affecting dissolution under biorelevant low velocity hydrodynamic conditions, using in vitro and in-silico methods
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The goals of the current study were to investigate the effect of hydrodynamics on the dissolution of non-disintegrating compacts in a low velocity environment. This work also studies the impact of hydrodynamics on the ... -
Absorption properties of non-steroidal anti-inflammatory drugs and their amino acid derivatives
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The principal objectives of this work were: i) to examine the absorption properties of ibuprofen in a range of different buffer solutions; ii) to study the absorption properties and mechanisms of ibuprofen, ketoprofen and ... -
Polyamines and polyamine antagonists in cerebral ischaemia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Polyamines are ubiquitous components of all eukaryotic cells and are found in brain tissue. A number of studies have shown that changes in the levels of polyamines occur following cerebral ischaemia. However, whether ... -
Novel pharmaceutical excipients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The research work performed in compiling this thesis can be divided into two broad areas, namely (a) the development, characterisation and examination of potential pharmaceutical applications of new de-aggregated grades ... -
The design, synthesis and biochemical evaluation of analogues of dehydroepiandrosterone (DHEA) and novel selective oestrogen receptor modulators (SERMs)
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)This thesis is presented in four sections. In the first section the synthesis of a series of B ring derivatives of dehydroepiandrosterone (DHEA) is described. DHEA is the most abundant steroid in human plasma and has been ... -
Development, validation and optimisation of a vHTS protocol for identification of estrogen receptor modulators
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)The discovery of small-molecule drugs has reached a critical point in time where the number of new drugs released to market has become static regardless of the technological advances observed over the last few years. ... -
An investigation of the role of the polyamines in epilepsy and cerebral ischaemia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)The polyamines, spermine and spermidine, are ubiquitous in nature but are found in especially high concentrations in brain tissue. The polyamines are required for cell growth and differentiation but in high doses are ... -
The pharmacological effects of novel isosorbide-based butyrylcholinesterase inhibitors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)This study sought to determine the pharmacological effects of novel isosorbide-based butyrylcholinesterase inhibitors (BuChEl’s) in vitro and in vivo. The potency of the novel compounds 2-benzylcarbamate 5-nicotinate ... -
Characterisation of drug-fatty acid composites and their use in drug delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Fatty acids are considered to be useful as carrier materials in the formulation of drug delivery systems. Literature on fatty acid systems, in particular, stearic acid, was reviewed, though in general, research in this ... -
Dual acting nuclear receptor targeting conjugates : design, synthesis and biochemical evaluation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Breast cancer has become the second most common cancer worldwide after lung cancer, the fifth most common cause of cancer death, and the foremost cause of cancer death in women. Worldwide, breast cancer exceeds all other ... -
Design, synthesis and biochemical evaluation of dual-acting, estrogen receptor ligand conjugates
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)Selective targeting of malignancies over healthy cells is an important goal in cancer therapies. Knowledge of environmental and biological differences between tumours and healthy tissue can present suitable targets for ... -
Novel formulations for use in the oral cavity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The aim of this thesis was to develop a number of novel products for use in the oral cavity. Periodontitis is a condition characterized by the loss of clinical attachment to the gum, along with resorption of the alveolar ... -
Studies in the synthesis and impurity profiling of Methylenedioxy and Alkylthioamphetamines
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)3,4-Methylenedioxymethamphetamme (MDMA, Ecstasy) and other, so-called, designer amphetamines, have become popular drugs of abuse over the past number of years. Detailed knowledge of the synthetic methods employed by ...
