Trinity College Dublin Theses & Dissertations: Recent submissions
Now showing items 1121-1140 of 7000
-
Mechanisms of gasdermin pore formation in response to viral sensing in human respiratory epithelial cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)A key component of the innate immune response to infection or cellular stress is the activation of inflammasomes which leads to gasdermin (GSDM) pore formation, interleukin-1β (IL-1β) release and lytic cell death. GSDMs ... -
Investigating the Impact of the Non-Structural Proteins of Respiratory Syncytial Virus on the Type I Interferon Response
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Respiratory syncytial virus is the leading cause of bronchiolitis in infants, causing 33.2 million hospital admissions and over 118,000 deaths each year. The primary site of RSV infection are the epithelial cells of the ... -
Predictive Microbiome Post-Bone Marrow Transplantation and Acute Graft versus Host Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Haemopoietic stem-cell transplantation serves as one of the life-saving options for the management of refractory haematological malignancies and rarely for non-malignant conditions. The era of transplantation has significantly ... -
Colour terms in Russian healing charms as expressions of illness and health
Healing charms have been in use for more than a thousand years and are part not only of Russian folklore, but also of the Russian folk healing system. This thesis explores the semantics of colour terms in healing charms, ... -
Assessment of indoor air quality in energy efficient residential buildings in Ireland
(Trinity College Dublin. School of Engineering. Disc of Civil Structural & Environmental Eng, 2023)Over the last two decades, Europe has witnessed a drive towards building energy efficiency. The EU directive on energy performance of buildings, as implemented in 2002, targeted the improvement in energy efficiency of ... -
Antipsychotics Prevent Psychosine Induced Toxicity in Glial Cells.
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2023)Glial cells are implicated in the neuropathophysiology of schizophrenia and other neuropsychiatric disorders. Also, the role of altered myelin in the onset and development of schizophrenia and changes in myelin due to ... -
Explanations and Familiarity in XAI: How users understand predictions and make decisions using an AI support system
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2023)We compared the effects of counterfactual and causal explanations for an Artificial Intelligence (AI) system?s decisions in a familiar domain (alcohol and driving) and an unfamiliar one (chemical safety) in four experiments ... -
Brian O'Nolan's Systems of Mediation
(Trinity College Dublin. School of English. Discipline of English, 2023)This thesis focuses on the significance of mediation in Brian O?Nolan?s body of work. The term `mediation' is used within the context of recent media theory such as that of Friedrich Kittler, and it refers to the way that ... -
People and Nature in anthropogenic landscapes: an ecological perspective
(Trinity College Dublin. School of Natural Sciences. Discipline of Botany, 2023)Nature-based Solutions have been a popular research topic within the sustainability literature for last decade. Conceived of as a more sustainable alternative to engineered solutions, solutions founded in nature are promised ... -
Prosodic Structure in Munster Irish
(Trinity College Dublin. School of Linguistic Speech & Comm Sci. C.L.C.S., 2023)This thesis centres on prosody (rhythm, intonation, and prominence) in the Munster varieties of Irish (Gaelic). Munster Irish (MI) is distinct from other varieties of the language in having a complex, weight-sensitive ... -
"Dads are there, they are not gone missing.": The Role and Involvement of Fathers/Dads in the Lives and Education of Children with Special Educational Needs and/or Disabilities (SEN/D) within an Early Intervention (EI) Context
(Trinity College Dublin. School of Education. Discipline of Education, 2023)For families of young children with special educational needs and/or disabilities (SEN/D), the role and involvement of fathers/dads in such a parenting context does not appear to be of much research interest. Regardless ... -
Human pressure as an ecological force across scales and systems
(Trinity College Dublin. School of Natural Sciences. Discipline of Zoology, 2023)Historically, climate has been seen as the main driver of global vegetation patterns, but ecological paradigms have recently expanded to acknowledge human activity as a critical determinant of species biogeography. Today, ... -
Inverse Problems in Disordered Systems
(Trinity College Dublin. School of Physics. Discipline of Physics, 2023)It is a simple Quantum Mechanics problem to find the electronic conductance of a device by directly solving the Schrodinger Equation. Obviously, this is the case if and only if the underlying Hamiltonian is known, i.e., ... -
A Question of Meaning: Motivation as a Meaning-Making Process for Late Adolescent Learners Engaged in Multilingual Language Learning
(Trinity College Dublin. School of Linguistic Speech & Comm Sci. C.L.C.S., 2023)Although we have advanced our knowledge of language learning motivation, there are still many elements that have not been sufficiently considered. Within the existing research, there is a lack of perspectives that focus ... -
The Worker and the Constitution: A Theory of Constitutional Labour Law
(Trinity College Dublin. School of Law. Discipline of Law, 2023)This thesis constructs a theoretical justification for the phenomenon of ?constitutional labour law? ? that is, legal decisions about the interaction between constitutional norms, including human rights, and the labour ... -
Innate immune potential of bovine respiratory epithelial cells: role in viral infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Respiratory epithelial cells have important defence activities against respiratory viruses. While their physical barrier function is well described, the molecular mechanisms responsible for how epithelial cells initiate, ... -
DEVELOPMENT OF SUSTAINABLE, ALKALI-ACTIVATED BINDERS FOR CONSTRUCTION
(Trinity College Dublin. School of Engineering. Disc of Civil Structural & Environmental Eng, 2023)This work contributes to the design and production of alkali-activated materials (AAMs) of lower environmental impact than Portland cement (PC) products. AAM binders result from the reaction of an activator and a precursor. ... -
The Lived Experiences of Nurses and Physicians Caring for Children with Complex Care Needs in Paediatric Intensive Care Units during the First Eighteen Months of the COVID-19 Pandemic.
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2023)The global pandemic caused by COVID-19 has affected the health and wellbeing of children across the world. Children with complex care needs (CCNs) have a range of health and social care needs, including physical, developmental, ... -
Evaluating the role of angiogenesis in disease behaviour and therapy response in ulcerative colitis
Introduction Ulcerative colitis (UC) is a chronic inflammatory condition with a significant impact on quality of life. In this thesis two small molecule anti-angiogenic and anti-inflammatory agents were used to treat tissue ... -
Essays in Productivity
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Economics, 2023)This dissertation is a collection of three essays linked through the common theme of the aggregation of productivity in motion. The first essay examines productivity trends in European Manufacturing through the movement ...
