Trinity College Dublin Theses & Dissertations: Recent submissions
Now showing items 1241-1260 of 7000
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Characterisation of Innate Immune and Metabolic Roles of SARM1 in Mouse Macrophages.
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Engagement of the NLRP3 inflammasome in response to injury or infection results in the activation of the pro-inflammatory protease, caspase-1. Cleavage of the caspase-1 substrate, gasdermin D (GSDMD), leads to the GSDMD ... -
INTEGRATED TRANSPORTATION AND LAND USE REGRESSION MODELLING FOR NO2 MITIGATION
(Trinity College Dublin. School of Engineering. Disc of Civil Structural & Environmental Eng, 2022)The transport industry has been identified as one of the main contributors to Nitrogen Dioxide (NO2) pollution in Ireland. Diesel fuelled vehicles emit significantly greater amounts of NO2 in comparison to any other fuel ... -
Determining the depths and timescales of pre-eruptive processes before the historical 1538 Monte Nuovo eruption (Campi Flegrei caldera, Italy)
(Trinity College Dublin. School of Natural Sciences. Discipline of Geology, 2022)Campi Flegrei, Italy is one of the most populated caldera volcanoes on Earth and a detailed understanding of its sub-volcanic magma system and pre-eruptive processes are essential for effective hazard mitigation. Of ... -
Single cell analysis of iNKT cell heterogeneity, phenotype, and function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of ... -
Development and characterisation of a humanised model of Parkinson's disease associated with delivery of adeno-associated virus expressing alpha-synuclein and pre-formed alpha-synuclein fibrils unilaterally into the rat substantia nigra
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Parkinson s disease (PD) is the most common motor neurodegenerative disease, characterised histologically by the presence of Lewy bodies, which are intracellular inclusions containing a variety of cellular proteins, the ... -
The Plasticity of Neutrophil Subsets in Inflammation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Neutrophils are a vital component of the innate immune system and the body s first line of defense against invading pathogens. The classic view of these cells is that they are a homogenous population of terminally ... -
Contesting Chronos: An Exploration of Competing Ontologies of Time in Early Greek Thought
(Trinity College Dublin. School of Histories & Humanities. Discipline of Classics, 2022)This thesis explores the diverse ontologies of time that are evidenced in the early Greek cosmologies of Hesiod, Pherecydes of Syros, and Empedocles. Through three case studies, I argue that in order to understand the ... -
Inward Investment in Northern Ireland and Policy Transfer North and South: 1945 - 1973
(Trinity College Dublin. School of Business. Discipline of Business & Administrative Studies, 2022)Inward Investment in Northern Ireland and Policy Transfer North and South: 1945 -1973 Alison Hearne Using a historical narrative approach (Fletcher and Godley, 2000; Godley 1999), this thesis consists of three interlinked ... -
Adversarial Robustness of Representation Learning for Knowledge Graphs
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2022)Knowledge graphs represent factual knowledge about the world as relationships between concepts and are critical for intelligent decision making in enterprise applications. New knowledge is inferred from the existing facts ... -
Spanners in the Works: Quality Professionals in Irish Higher Education
In the context of the debate as to the future of Irish higher education, the purpose and identity of emerging professional roles such as quality offices and education developers that straddle both the academic and ... -
The role of tissue-resident memory T cells in immunity to Bordetella pertussis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Whooping cough (pertussis) is a severe respiratory disease cause by the Gram-negative bacterium Bordetella pertussis. Despite high vaccine coverage, a resurgence of pertussis has been observed over recent years. Although ... -
An investigation into diffusion tensor imaging-derived metrics in arterial tissue as biomarkers for disease progression, plaque rupture and graft recellularisation
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Non-invasive imaging offers great potential for several clinical applications, both in disease and treatment monitoring. Specifically, within vascular tissue better clinical indicators for vulnerable atherosclerotic plaque, ... -
Triplet Photosensitisers: From Molecular Designto Light-Driven Applications
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Transition metal complexes, particularly Ir(III) and Ru(II), exhibit attractive photophysical properties and have long been the subject of scientific research owing to their use in various light-driven applications. This ... -
A Pragmatic Bishop: George Berkeley's Theory of Causation in De motu
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Philosophy, 2022)In this doctoral thesis, I will argue that in his De motu (1721, 'On motion'), Bishop George Berkeley (c.1684-1753) develops a pragmatist theory of causation regarding mechanical theories outlined previously with Newtonianism. ... -
Tumour derived microRNA-21 reprograms macrophage responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)The role of the oncogenic yet anti-inflammatory microRNA-21 (miR-21) in the tumour microenvironment (TME) is not clearly defined, despite its upregulation in many cancers. Since re-education of macrophages by tumour derived ... -
Can you mold, handle or portray it? Iconicity and metaphor in depiction strategies in co-speech gesture
(Trinity College Dublin. School of Linguistic Speech & Comm Sci. C.L.C.S., 2022)The study explores iconicity and metaphor revealed in various gestural depiction strategies in co-speech representational gestures (Kendon, 2004; David McNeill, 1992). The gesture examples have been sourced from three ... -
Selective Deposition: Fabrication of Coherent Nano-Dimensioned Metal Oxide Films by Monolayer Polymer Brush Template Assisted Inclusion
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022) -
Re-evaluating the Role of SARM1 as a Transcriptional Regulator Using Improved Genome-Edited Mouse Models
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)SARM1 is an ancient and highly conserved protein, initially described as having functions in innate immunity. In the last decade, our understanding of SARM1 structure and function expanded rapidly. The majority of research ... -
Deterrence and Asylum: A comparative socio-legal perspective on the credibility assessment of separated children seeking international protection
(Trinity College Dublin. School of Law. Discipline of Law, 2022)The number of separated children seeking asylum in Europe has increased substantially over recent years. While it is acknowledged that separated children seeking asylum pose additional unique challenges for refugee status ... -
Denoising approaches for data preparation in machine learning
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2022)Machine-learning models have been recently developed in various computer vision applications, such as image detention, segmentation and so on. Models are often trained based on data that present various levels of accuracy, ...
