Trinity College Dublin Theses & Dissertations: Recent submissions
Now showing items 141-160 of 7000
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The Nature, Severity and Impact of Chronic Oropharyngeal Dysphagia following Oesophageal Cancer Surgery
(Trinity College Dublin. School of Linguistic Speech & Comm Sci. Discipline of Clin Speech & Language Studies, 2025)Introduction: People with oesophageal cancer often experience dysphagia from before diagnosis to many years beyond treatment which may be directly secondary to the tumour obstructing the oesophagus, from tumour related ... -
Insular glass and amber studs, seventh to twelfth century AD: dating, chronology and workshop practice
(Trinity College (Dublin, Ireland). Department of History of Art and Architecture, 2017)Studs of glass and amber are found alongside panels of gold filigree and embossed silver foils, are an integral part of high status Insular metalwork created between the seventh and twelfth centuries. No over-arching survey ... -
Characterising the Effect of Hypoxic Conditions on Extracellular Vesicle Release and Function in Triple-Negative Breast Cancer
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)Hypoxia is a hallmark of many solid tumours and is strongly associated with cancer progression and metastasis. Triple-negative breast cancer (TNBC), an aggressive subtype lacking targeted therapies, exhibits more pronounced ... -
Peptidic Activity Based Probes to Understand the Deubiquitination Machinery
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)Ubiquitination is a highly conserved post-translational modification (PTM) that governs numerous critical cellular events such as protein degradation and membrane import/export. Such process is tightly regulated by a complex ... -
Differential Pathogenic Mechanisms Driving Stromal Cell Inflammatory Pathways in RA and PsA
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)Rheumatoid arthritis (RA) and Psoriatic arthritis (PsA) encompass two of the most prevalent forms of inflammatory arthritis (IA), an umbrella term for the vast range of autoimmune driven arthropathies characterised by ... -
Machine Learning-Assisted Dynamic Modelling of Wind Turbine Blades for Response Prediction
(Trinity College Dublin. School of Engineering. Disc of Civil Structural & Environmental Eng, 2025)The wind energy sector has seen significant growth in the last few decades in terms of the number of wind turbines constructed and the scale of these structures. Multimegawatt wind turbines on scales previously unimaginable ... -
`Trust Contexts' - A Grounded Theory Study of Women's Experience of Healthcare Interactions in Pregnancy and Birth in Ireland.
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, School of Nursing and Midwifery, 2025)Background: Reproductive rights are often considered in relation to reproductive choices like contraception and termination of pregnancy. However, reproductive rights are equally relevant in pregnancy and childbirth and ... -
Designing Hand-Object Interaction Representations For Better Grasp Priors
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2025)Accurate modelling of hand-object interactions (HOI) is critical for applications in areas such as computer vision, augmented/mixed/virtual reality, video games production and robotics. In computer vision, HOI modelling ... -
Beyond Glucose Control: The Impact of Metformin on the Appetite-Suppressing Metabolite Lac-Phe and Fatty Acid Metabolism in Humans
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels, suppress appetite, and exert anti-inflammatory effects. However, despite extensive research on its clinical ... -
Design and Synthesis of Potent and Selective Anticancer Compounds Targeting Tubulin Polymerisation and Aminopeptidase N
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)This thesis describes the synthesis and evaluation of novel drug conjugates targeting aminopeptidase N (APN) (E.C. 3.4.11.2) and tubulin dynamics. Chapter 1 opens with a thorough review of the existing literature on ... -
Morphological & Electrical Characterisation of Nanosheet Networks
(Trinity College Dublin. School of Physics. Discipline of Physics, 2025)Since the discovery of the stability and excellent electrical properties of the graphene monolayer, there has been a great deal of excitement about the superlative electrical, mechanical and thermal properties of 2D ... -
Complex Trauma in Childhood: Informing Occupational Therapy Practice
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2025)Background: There is a dearth of evidence available to support occupational therapy practice with children experiencing complex trauma. No occupational therapy-specific guidelines exist. The occupational experiences of ... -
Novel Technique for Developing E-Textiles: Printing MXene Supercapacitors on Fabrics for Wearable Electronics
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2025)The increasing demand for miniaturised and flexible wearable electronics is driving the rapid growth of electronic textiles (e-textiles). In this context, microsupercapacitors (MSCs) are becoming essential as energy storage ... -
Newly Qualified General Nurses' experiences and the perceived value of their internship period: a Republic of Ireland cross-sectional study.
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2025)Background: A 36-week nursing internship was introduced as part of the undergraduate nursing degree programme in Ireland in 2002. This development was intended to provide final year nursing students with extended clinical ... -
Thermodynamics of Nanoelectromechanics
(Trinity College Dublin. School of Physics. Discipline of Physics, 2025)Taking inspiration from nanoelectromechanical experiments, we introduce a microscopic toy model consisting of a resonant-level quantum dot coupled to two electrodes and a single-mode oscillator. We derive a Fokker-Planck ... -
Systematic Investigation of Cold Spray for the Manufacturing of Tantalum-Silver Composites
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2025)This work investigates the fabrication and properties of tantalum-silver (Ta-Ag) composites produced using cold spray technology. Despite the inherent immiscibility of Ta and Ag, Ta-Ag composites were successfully fabricated ... -
A Qualitative Exploration of Living with and Managing Post COVID-19 Condition
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2025)Background: Post COVID-19 condition, or long COVID, has been largely studied via quantitative assessments, focusing on symptom prevalence and severity. However, limited research has explored how individuals experience the ... -
Revolutionary Imaginaries and Legacies in Postrevolutionary Chinese Theatre: Amnesia, Nostalgia, Melancholia, Heterotopia, Cosmopolitanism
(Trinity College Dublin. School of Creative Arts. Discipline of Drama, 2025)This thesis is a study of postrevolutionary Chinese theatre from the 1980s to the 2010s to explore how revolutionary and socialist legacies, ruins, and memories are reimagined, re-membered, represented on the stage. I ... -
PLGA particle size as a critical modulator of immune tolerance via ⍺vβ3 mechano-sensor engagement
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)The increasing prevalence of inflammatory and autoimmune conditions underscores the critical need for novel therapeutic strategies that modulate inflammation without impairing the capacity to mediate protective immunity ... -
Exploring Explainable Artificial Intelligence (XAI) in Telecommunication Networks
(Trinity College Dublin. School of Engineering. Discipline of Electronic & Elect. Engineering, 2025)Artificial intelligence (AI) is poised to become a key technology in future telecommunication networks due to its profound ability to solve complex tasks in a data-driven and, in some cases, model-free manner. Although AI ...
