Trinity College Dublin Theses & Dissertations: Recent submissions
Now showing items 241-260 of 7000
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Sarcopenia and Orthostatic Hypotension: Investigating the Underlying Haemodynamics
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2025)The ageing population worldwide is both one of the greatest successes of modern humanity and one of its greatest challenges. These challenges are numerous and include the geriatric syndromes of sarcopenia and orthostatic ... -
Folate and Vitamin B12 in The Irish Longitudinal Study on Ageing cohort: associations with cognitive function
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2024)The aim of this Ph.D. thesis is to examine nutrition, cognitive and autonomic dysfunction in the older population in Ireland. One review and five separate quantitative studies are presented in this thesis, which use data ... -
Plunge Stage Force Reduction in Friction Stir Spot Welding of AA2024-T3 through Implementation of Assistive-Auxiliary Energy
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2024)The increasing demand for lightweight, high-strength structures necessitates materials with superior strength-to-weight ratios and advanced technologies like Friction StirWelding (FSW). Since its inception in 1991, FSW has ... -
Sunshine genomics: a gene-environment interaction approach to the study of the genetic determinants of vitamin D status and skin cancer
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2025)Complex health traits are shaped by the interplay between genetic and environmental factors. Understanding the contributions of these factors is particularly important for traits such as vitamin D status and skin cancer ... -
Essays in Empirical Macroeconomics
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Economics, 2025)This thesis is a collection of three independent essays. The objective of the research is to answer three major questions faced by Central Banks and policymakers in Europe that have arisen since the Global Financial ... -
Art and Material Culture as Instruments of Gendered Self-Fashioning in the Life of Isabel Farnesio (1692-1766)
(Trinity College Dublin. School of Histories & Humanities. Discipline of History Of Art, 2024)This thesis takes as its central focus Isabel Farnesio, exploring the ways in which her engagement with art reflected and buttressed her construction of identity. Born Elisabetta Farnese, the Princess of Parma in 1692, and ... -
Accuracy of Predicting Treatment Adjuncts for Patients Requiring Special Care Dentistry
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2025)Background: Predicting the correct treatment adjuncts in special care dentistry (SCD), such as non-pharmacological behavioural support, inhalation sedation, intravenous (IV) sedation, or general anaesthesia (GA), can be ... -
Vaccine-induced tissue-resident memory T cells and mucosal immunity to respiratory pathogens
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Respiratory infections cause considerable morbidity and mortality globally, in particular in the most vulnerable individuals in our societies. Whooping cough (pertussis) is a respiratory disease caused by the Gram-negative ... -
Understanding T cell Immunity in Atopic Dermatitis: Relevance to Staphylococcus aureus Vaccine Design
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2025)In this thesis, I present original research investigating the T cell response to S. aureus in paediatric atopic dermatitis (AD). The aim of this study is to investigate the memory T cell immune response to S. aureus in ... -
Essays in International Macroeconomics and Economic Inequality
(Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Economics, 2025)This thesis consists of four essays at the intersection of international macroeconomics and economic inequality. Each chapter tackles important questions aimed at understanding the relevant macroeconomic dynamics between ... -
I'll Know It When I See It: Bridging Perception and Conceptual Learning in Minds and Machines
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2025)Recognising and understanding what we see is essential throughout life, from infancy to adulthood. While advances in brain imaging and computational models have shed light on how the adult brain processes visual information, ... -
Design and Analysis of Biodiversity Experiments
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Statistics, 2025)Biodiversity and ecosystem functioning (BEF) relationships define the ways in which the diversity of species in an ecosystem drive the quantity and quality of the goods and services provided. Species diversity may be defined ... -
VINCI-AD: Investigating Transcutaneous Vagus Nerve Stimulation in Amnestic Mild Cognitive Impairment
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2025)Abstract Introduction New treatments are urgently needed for individuals with Mild Cognitive Impairment (MCI) - in particular for those with amnestic MCI as they are at highest risk for developing dementia. Transcutaneous ... -
Tracking Solar Electron Beams from the Corona to the Heliosphere using Bayesian Methods
(Trinity College Dublin. School of Physics. Discipline of Physics, School of Physics, 2025)The Sun is an active star that produces the most powerful phenomena in the solar system, particularly flares and coronal mass ejections (CMEs). These violent explosions accelerate electrons and other solar energetic particles ... -
Solid-State Transformations of Fluoroquinolones Induced by Mechano- and Tribo-Chemical Processes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2025)Mechano- and tribo-chemistry is growing at a fast rate. However, more scientific contributions need to be made in order to better understand this type of chemistry and processing so that it can be implemented into the ... -
Patient Non-Attendance Appointment Study A mixed methods study to evaluate the problem of missed appointments at the Radiology outpatient department in King Fahad Specialist Hospital, Saudi Arabia, and the implementation and evaluation of an intervention to improve outpatient appointment attendance in this department.
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2025)Aims: The aim of this study was to evaluate the prevalence of appointment non-attendance within the Radiology Department at King Fahad Specialist Hospital and to identify the factors contributing to missed appointments. ... -
Metabolic characterisation and modulation of the immune response to biomaterials for bone tissue engineering
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)The limited capacity of many tissues and organs to adequately repair and regenerate lies at the heart of numerous healthcare challenges. Difficulties faced in promotion of tissue healing and regrowth have begun to be tackled ... -
Targeting DNA Damage Repair Deficiency in Pancreatic Cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, School of Medicine, 2024)Pancreatic ductal adenocarcinoma is a lethal disease with a 5-year survival of <12%. Approximately 5-10% of the patients have BRCA1/2 mutations which cause homologous recombination (HR) deficiency and sensitise to cisplatin ... -
Clonal haematopoiesis in telomere biology disorders influences risk of haematological malignancy and overall survival
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Telomere biology disorders (TBD) are a spectrum of diseases caused by germline variants in telomere repair and maintenance. They comprise one of the inherited bone marrow failure syndromes, a heterogenous group of disorders ... -
Krylov Subspace Recycling For Matrix Functions
(Trinity College Dublin. School of Mathematics. Discipline of Pure & Applied Mathematics, 2024)The work in this thesis is concerned with the development of Krylov subspace recycling algorithms for the efficient evaluation of a sequence of matrix function applications on a set of vectors. Recycling methods are a ...
