Trinity College Dublin Theses & Dissertations: Recent submissions
Now showing items 421-440 of 7000
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Integrating non-viral gene therapy and 3D bioprinting for bone, cartilage and osteochondral tissue engineering
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)The repair of osteochondral defects, affecting both the articular cartilage and the underlying subchondral bone, is key for the effective recovery of joint homeostasis and the prevention of further cartilage degeneration ... -
The growth and characterization of Chromium-based p-type transparent conducting oxides
(Trinity College (Dublin, Ireland). School of Physics, 2016)Two Cr-related materials Cr203 and CuCr02 are investigated as p-type transparent conducting oxides. They both have Cr in its electron configuration, a feature that is responsible for the p-type conductivity. Epitaxial Cr203 ... -
Nanoporous anodic aluminium oxide for magnetic, mechanical and energy efficient systems
(Trinity College (Dublin, Ireland). School of Physics, 2016)This dissertation presents four different aspects of magnetism in relation to Anodic Aluminium Oxide (AAO) membranes. The fabrication of nanoporous AAO templates has been extensively studied in last two decades using the ... -
Induction of anti-tumour immune responses by overcoming tumour immune subversion
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Immunotherapy has considerable potential to improve disease outcome and survival of patients with cancer. Tumour eradication by the immune system is largely dependent on pro-inflammatory signals and effector cell infiltration ... -
Oesophageal adenocarcinoma cell migration and metastasis : an investigation of the scaffolding protein RACK1 as a key player and therapeutic target
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)The incidence of oesophageal adenocarcinoma is increasing at a rapid rate in Western countries (Pennathur et al., 2013). Early oesophageal cancer is often asymptomatic and metastatic disease is common at presentation leading ... -
Static and dynamic magnetic interactions in graphene and related materials
(Trinity College (Dublin, Ireland). School of Physics, 2016)Since its discovery in 2004, graphene has been the recipient of both intense research and media attention. Graphene's properties reads as a list of superlatives, and its applications are vast and diverse. However, in this ... -
Expression and functional analysis of nucleic acid sensors in the CNS : implications for infection, sterile brain injury and neurodegeneration
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)The recognition of nucleic acids is essential in combating viral and bacterial pathogens. The sensors and pathways involved in RNA/DNA detection have only recently been discovered and have expanded over the last number of ... -
Reading between the lines : modelling and recognition of paralinguistic phenomena
(Trinity College (Dublin, Ireland). Department of Electronic & Electrical Engineering, 2016)The ability to understand the paralinguistic content of speech is central to the design of more natural human computer interfaces [106]. In this thesis we explore the detection of two types of speaker traits, emotion and ... -
The promotion of human dignity : a theory of Tort Law
(Trinity College (Dublin, Ireland). School of Law, 2017)Tort law is viewed by many academic and practitioners as a mixed bag of legal rules with no coherent seam linking its different parts. This view can be traced back to its historical development where tort law became the ... -
Exploring bilingual cognition in younger and older adults and second language learners
(Trinity College (Dublin, Ireland). School of Psychology, 2017)There is extensive research investigating the benefits of bilingualism on the ways that basic cognitive abilities develop, function and change throughout the lifespan, particularly from cohorts at either end of the ... -
The role of hagB and hagC in the virulence of Porphyromonas gingivalis and indentifcation of putative novel virulence factors by Transposon-Seq
(Trinity College (Dublin, Ireland). School of Dental Science, 2016)The haemagglutinin genes of P. gingivalis are believed to play an important role in the virulence of the organism. A subset of these genes, namely hagB and hagC, are distinct from the other family members based on nucleotide ... -
Genomic and transcriptomic profiling of Coeliac Disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Coeliac Disease (CD) is a chronic immune mediated disease triggered by the ingestion of gluten. It has an estimated prevalence of approximately 1% in European populations. Genome-wide association studies (GWAS) have ... -
Homomorphic encryption in the attribute-based setting
(Trinity College (Dublin, Ireland). School of Computer Science & Statistics, 2016)The main research question addressed by this thesis is whether we can combine a cryptographic primitive called homomorphic encryption with a cryptographic primitive called attribute based encryption. Firstly, let us define ... -
Neutrophil-derived proteases act as global regulators of IL-1 family cytokine activation states
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)IL-1 family cytokines are pleiotropic cytokines capable of eliciting robust proinflammatory cytokine and chemokine secretion from a broad variety of cell types and tissues. Recent evidence has strongly implicated IL-36 ... -
Investigation into the role of MNDA in the type 1 1FN response in human monocytes
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Type I interferons (IFNs) are secreted by cells in response to pattern recognition receptor (PRR) stimulation by viral nucleic acids and have a broad range of antiviral effects. The human PYHIN proteins, namely AIM2, IFI16, ... -
Biodiversity impacts of legume-supported cropping in Europe
(Trinity College (Dublin, Ireland). Department of Botany, 2016)Current global biodiversity loss is mainly driven by anthropogenic activities including land use change, pollution and over exploitation. Legumes have for millennia been used as a source of nitrogen in agriculture, and may ... -
Probing the role of joint specific environmental cues in guiding stem cell fate
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2016)Due to their relative ease of isolation, ability to proliferate extensively in vitro and to differentiate along multiple lineage pathways, mesenchymal stem cells / multipotent stromal cells (MSCs) are a promising cell type ... -
Spectroscopic studies of electronic structure in pristine and defective transition metal oxides
(Trinity College (Dublin, Ireland). School of Physics, 2016)Electronic structure measurements of materials in the presence of defects are inherently useful to advance our understanding of a materials properties. Within the paradigm of electromigration in Ti02 there are opportunities ... -
The effect of cigarette smoking on inflammatory, immunological and metabolic profiles in ulcerative colitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Ulcerative Colitis (UC) is an idiopathic form of inflammatory bowel disease characterised by chronic or relapsing inflammation in the colon. The pathogenesis of UC remains largely unknown but it is widely believed to be ... -
TCO/Dielectric superlattice structures for the decoupling of electrical and optical properties
(Trinity College (Dublin, Ireland). School of Physics, 2017)In this thesis [Transparent Conducting Oxide (TGO)/Dielectric] superlattices are discussed as a methodology for the decoupling of optical and electrical properties and for the theoretical combining of the properties of ...
