Trinity College Dublin Theses & Dissertations: Recent submissions
Now showing items 541-560 of 7000
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A Comparison of Spray drying and Liquid Antisolvent Co-precipitation for the Generation of Two- and Three- component Amorphous Solid Dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)The thesis focuses on the use of different manufacturing techniques for the generation of amorphous solid dispersions (ASDs) for the enhancement of the solubility of model compounds. ASDs with hydrochlorothiazide (HCTZ) ... -
Analysis of how the TCA cycle enzymes Fumarate hydratase and Succinate dehydrogenase regulate cytokine production
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Mitochondria are organelles which release metabolites and nucleic acids that act as signals to regulate immune cell activation and cytokine production. Tricarboxylic acid (TCA) cycle metabolites and enzymes have ... -
Furazano[3,4-d]pyrimidines and phosphazene pteridines as new tools in organic chemistry
(Trinity College (Dublin, Ireland). School of Chemistry, 1998)This thesis explores the use of 5,7-diaminofurazano[3,4-d]pyrimidine (64) (R = NH2) for the design of a pro-drug system which is stable in media of pH less than 5 but releases the active drug at pH values greater than 5. ... -
An Investigation of the Self-Assembly of Luminescent Lanthanide Architectures Using Novel Triazole-Pyridine Derivatives
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)Supramolecular assemblies based on some lanthanide ions (Ln = Nd(III), Sm(III), Eu(III), Tb(III), Dy(III), Er(III), Tm(III), Yb(III)) may have luminescent properties and have shown promise in applications such as sensing, ... -
Positioning Human Rights of Older People in Long-term Care in Ireland- a Foucauldian Critical Discourse Analysis
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2024)Human rights have been positioned as basic principles which apply to everyone. However, there are frequent reports of breaches of human rights when older people access long-term care (LTC), with heightened debate during ... -
Strategies to Stabilise Peptide Secondary Structure Using Unnatural Amino Acid Crosslinking
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)The communication between proteins plays a pivotal role in both biological and pathological processes. Protein-protein interactions (PPIs) play crucial roles in transcription, signal transduction and apoptosis; as such, ... -
Optimisation of non-Markovian systems using tensor networks
(Trinity College Dublin. School of Physics. Discipline of Physics, 2024)Structured environments that do not admit simple time-local descriptions display a wealth of features which are otherwise absent from unstructured environments. Here we use optimal control to learn how to perform quantum ... -
Dante, Political Theology & The Divine Comedy
(Trinity College Dublin. School of Religion. Irish School of Ecumenics, 2024)Despite the vast critical interest in Dante Alighieri's (1265-1321) theology and philosophy there still remains much work to be done in order to identify and appreciate more fully and critically his political theology, ... -
Open innovation is the new currency–Investigating how firms can maximize the effectiveness of open innovation initiatives
(Trinity College Dublin. School of Business. Discipline of Business & Administrative Studies, Trinity Business School, Trinity College Dublin, the University of Dublin, 2024)Open innovation has gained increasing prevalence not only because of its role in enhancing business performance and new product development success, but also of its potential to tackle complex societal issues. However, ... -
A comparative study of the juvenile justice systems of Northern Ireland and the Republic of Ireland
(Trinity College (Dublin, Ireland). Department of Sociology, 1984)This thesis consists of a comparative analysis of the trends in social policy in relation to the juvenile justice systems in Northern Ireland and the Republic of Ireland. The work has addressed several key issues relating ... -
Exploring the Experiences of Autistic Graduate Women in Navigating the World of Work
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2024)International research highlights poor prospects for autistic individuals in gaining and maintaining work (Baldwin et al., 2014; Harvery et al., 2021; Hendricks, 2010; Maslahati et al., 2022; Scott et al., 2019). Participation ... -
Synthetic Routes to Greener Pastures: A Sustainable View Towards Biomedically Relevant Magnetic Nanomaterials
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)Magnetic nanomaterials such as the spinel-type oxides, MFe2O4 (M = Fe2+, Co2+, Ni2+, Zn2+) have emerged as key materials in nanomedicine, with highly tuneable properties, accessed by varying composition or surface modification ... -
Characterisation of the Flow and Heat Transfer Behaviour Associated with a Wall-Bounded Dual Jet Flow
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2024)The purpose of this investigation is to characterise the fluid flow and heat transfer behaviour of a dual jet comprising a wall jet, discharged immediately parallel to a solid boundary, flowing alongside a parallel jet ... -
Margins of Learning: A Critical Analysis of the Scholia on Apollonius' Argonautica
(Trinity College Dublin. School of Histories & Humanities. Discipline of Classics, 2024)The scholia on Apollonius’ Argonautica constitute a substantial and varied corpus but have been overlooked by modern scholarship. This thesis seeks to fill that gap by providing a critical evaluation of the Argonautica ... -
Exploring the potential impact of collaborative medicines optimisation involving pharmacogenomic testing and general practice pharmacists in primary care in Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, University of Dublin, Trinity College, 2024)Introduction People are living longer, but not necessarily in better health. The ageing population coupled with the rise in chronic conditions has led to many older people being prescribed polypharmacy, which may not always ... -
The Magnetic, Magneto-transport and Magneto-optical Properties of Mn4-xGaxN Thin Films
(Trinity College Dublin. School of Physics. Discipline of Physics, 2024)Thin film Mn4N has recently gained a lot of attention for possible use in spintronic applications, owing to its perpendicular magnetic anisotropy (PMA), low saturation magnetisation and large anomalous Hall effect (AHE). ... -
INCOT: Irish Neonatal Care in Occupational Therapy Study: The Development of an Occupational Therapy Intervention for Neonatal Units in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2024)Background: Occupational therapists (OTs) play an important role in neonatal units internationally. This is a growing area of practice in Ireland, but it is not yet part of the standard of care in all neonatal units. ... -
Seismic Tomography of South America: Continental Lithosphere, Subduction-Zone Structures, and the Origins of Intraplate Magmatism
(Trinity College Dublin. School of Natural Sciences. Discipline of Geology, 2024)The lithospheric structure of South America records its long and complex tectonic evolution, during which it has influenced the distribution and composition of local magmatism, the geometry of the subduction at its western ... -
Investigation of Polymer-based Responsive Photonic Structures Fabricated by Two Photon Polymerisation
(Trinity College Dublin. School of Physics. Discipline of Physics, 2024)In this thesis, various 2D and 3D submicron polymer-based photonic structures are investigated for structural colour generation. 2D diffractive gratings have been designed and theoretically investigated by using ... -
Investigation of oral problems using a novel oral symptom assessment tool in patients with advanced cancer and older patients with frailty.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, School of Medicine, 2024)Oral symptoms are common in patients with advanced cancer. Certain oral symptoms like xerostomia are common in older patients. The prevalence of many oral symptoms is however unknown in older patients with frailty. Oral ...
