| dc.contributor.author | O'NEILL, LUKE | |
| dc.date.accessioned | 2016-09-27T14:16:03Z | |
| dc.date.available | 2016-09-27T14:16:03Z | |
| dc.date.created | 2015 | en |
| dc.date.issued | 2015 | en |
| dc.date.submitted | 2015 | en |
| dc.identifier.citation | LUKE O'NEILL, 'Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages', 2015, Journal of Biological Chemistry;, 290;, 33; | en |
| dc.identifier.other | Y | |
| dc.description.abstract | Background: The antidiabetic drug and mitochondrial NADH:ubiquinone oxidoreductase (complex I) inhibitor metformin has anti-inflammatory activity. Results: Complex I inhibition decreases LPS-induced IL-1β and boosts IL-10. Mitochondrial ROS may be a signal driving LPS-induced IL-1β. Conclusion: Complex I has a role in the induction of cytokines by LPS. Significance: This study provides insight into the anti-inflammatory action of metformin and reveals a role for complex I dysfunction in inflammatory signaling | en |
| dc.description.sponsorship | *This work was supported by the European Research Council and Science Foundation Ireland. The authors declare that they have no conflicts of interest with the contents of this article. | en |
| dc.format.extent | 20348 | en |
| dc.format.extent | 20359 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Journal of Biological Chemistry; | |
| dc.relation.ispartofseries | 290; | |
| dc.relation.ispartofseries | 33; | |
| dc.rights | Y | en |
| dc.subject | antidiabetic drug | en |
| dc.subject.lcsh | antidiabetic drug | en |
| dc.title | Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/laoneill | |
| dc.identifier.rssinternalid | 128149 | |
| dc.identifier.doi | http://dx.doi.org/10.1074/jbc.M115.662114 | |
| dc.rights.ecaccessrights | openAccess | |
| dc.identifier.rssuri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84939625498&partnerID=40&md5=47d41baddf6e7dba19feb4146a8d2e59 | |
| dc.contributor.sponsor | Science Foundation Ireland | en |
| dc.identifier.uri | http://hdl.handle.net/2262/77441 | |
