| dc.contributor.author | MARTIN, SEAMUS | en |
| dc.date.accessioned | 2017-01-12T12:47:46Z | |
| dc.date.available | 2017-01-12T12:47:46Z | |
| dc.date.created | 2016 | en |
| dc.date.issued | 2016 | en |
| dc.date.submitted | 2016 | en |
| dc.identifier.citation | Henry C.M, Sullivan G.P, Clancy D.M, Afonina I.S, Kulms D, Martin S.J, Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines, Cell Reports, 14, 4, 2016, 708 - 722 | en |
| dc.identifier.other | Y | en |
| dc.description | PUBLISHED | en |
| dc.description | Cited By :11 Export Date: 6 January 2017 | en |
| dc.description.abstract | IL-36 cytokines require proteolytic
processing for activation, but how this is
achieved is unknown. Here, Henry et al.
show that proteases liberated from
activated neutrophils—cathepsin G,
elastase, and proteinase-3—differentially
process and activate all three IL-36 family
members. Therefore, neutrophil-derived
proteases can escalate inflammation
through processing of extracellular
cytokines. | en |
| dc.description.sponsorship | We thank Dr. Yutaka Shimomura for provision of the IL-36R plasmid. We thank Dr. Eva Palsson-McDermott (TBSI, Trinity College Dublin) for assistance with neutrophil preparations. The S.J.M. laboratory is supported by a principal investigator award (SFI/14/IA/2622) grant from the Science Foundation Ireland. | en |
| dc.format.extent | 708 | en |
| dc.format.extent | 722 | en |
| dc.relation.ispartofseries | Cell Reports | en |
| dc.relation.ispartofseries | 14 | en |
| dc.relation.ispartofseries | 4 | en |
| dc.rights | Y | en |
| dc.subject | IL-36 cytokines | en |
| dc.subject.lcsh | IL-36 cytokines | en |
| dc.title | Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/martinsj | en |
| dc.identifier.rssinternalid | 141421 | en |
| dc.identifier.doi | http://dx.doi.org/10.1016/j.celrep.2015.12.072 | en |
| dc.rights.ecaccessrights | openAccess | |
| dc.identifier.rssuri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84958115094&doi=10.1016%2fj.celrep.2015.12.072&partnerID=40&md5=6d57672255a160cc58902d511a6cbc84 | en |
| dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
| dc.contributor.sponsorGrantNumber | SFI/14/IA/2622 | en |
| dc.identifier.uri | http://hdl.handle.net/2262/78702 | |
