Browsing Mechanical, Manufacturing & Biomedical Eng by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 101-120 of 125
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Potential for combined delivery of riboflavin and all-trans retinoic acid, from silk fibroin for corneal bioengineering.
(2019)Millions of people worldwide suffer from vision impairing conditions resulting from corneal injury or disease. Silk fibroin (SF) is an emerging biopolymer that has been used for several applications including the fabrication ... -
Promoting endogenous articular cartilage regeneration using extracellular matrix scaffolds
(2022)Articular cartilage defects fail to heal spontaneously, typically progressing to osteoarthritis. Bone marrow stimulation techniques such as microfracture (MFX) are the current surgical standard of care; however MFX typically ... -
Proxy measurement and strategic metering methodologies for resource transparency of industrial systems
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)For the latest advancement of manufacturing systems, namely Industry 4.0 or Smart Manufacturing, large amounts of precise process data are required. However, the acquisition of sufficient data represents a challenge for ... -
Quantification of Subsurface Damage in a Brittle Insulating Ceramic by Three-Dimensional Focused Ion Beam Tomography
(2011)In this study, we present a fully automated method to investigate and reconstruct the three-dimensional crack structure beneath an indent in a highly insulating material. This work concentrates on issues arising from a ... -
RANKL and OPG activity is regulated by injury size in networks of osteocyte-like cells
(2011)Bone remodelling is an intricate process encompassing numerous paracrine and autocrine biochemical pathways and mechanical mechanisms. It is responsible for maintaining bone homeostasis, structural integrity and function. ... -
Rat tail models for the assessment of injectable nucleus pulposus regeneration strategies
(2022)Back pain is a global epidemiological and socioeconomic problem often associated with intervertebral disc degeneration; a condition believed to initiate in the nucleus pulposus (NP). There is considerable interest in ... -
Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites
(2020)Engineering constructs that mimic the complex structure, composition and biomechanics of the articular cartilage represents a promising route to joint regeneration. Such tissue engineering strategies require the development ... -
Resident macrophages and their potential in cardiac tissue engineering
(2021)Many facets of tissue engineered models aim to understand cellular mechanisms to recapitulate in vivo behavior, study and mimic diseases for drug interventions and to provide better understanding towards improving regenerative ... -
Review—Towards the Two-Dimensional Hexagonal Boron Nitride (2D h-BN) Electrochemical Sensing Platforms
(2020)Electrochemical sensing performance of two-dimensional hexagonal boron nitride (2D h-BN) has traditionally been suppressed by their intrinsic electrical insulation and deficient electron transportation mechanism. However, ... -
A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells.
(2011)Bone turnover is a mechanically regulated process, coordinated in part by the network of mechanosensitive osteocytes residing within the tissue. The recruitment and bone forming activity of the mesenchymal derived osteoblast ... -
The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells
(2010)It is becoming increasingly clear that mesenchymal stem cell (MSC) differentiation is regulated by mechanical signals. Mechanical forces generated intrinsically within the cell in response to its extracellular environment, ... -
The Scissors Model of Microcrack Detection in Bone: Work in Progress
(2010)We have proposed a new model for microcrack detection by osteocytes in bone. According to this model, cell signalling is initiated by the cutting of cellular processes which span the crack. We show that shear displacements ... -
Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive strains using a lattice modeling approach
(2010)Mechanical stimuli are one of the factors that influence tissue differentiation. In the development of biomaterials for bone tissue engineering, mechanical stimuli and formation of a vascular network that transport oxygen ... -
Sliding bubble dynamics and the effects on surface heat transfer
(2012)An investigation into the eff ects of a single sliding air bubble on heat transfer from a submerged, inclined surface has been undertaken. Existing literature has shown that both vapour and gas bubbles can increase heat ...