Mechanical, Manufacturing & Biomedical Eng: Recent submissions
Now showing items 221-240 of 952
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Review—Towards the Two-Dimensional Hexagonal Boron Nitride (2D h-BN) Electrochemical Sensing Platforms
(2020)Electrochemical sensing performance of two-dimensional hexagonal boron nitride (2D h-BN) has traditionally been suppressed by their intrinsic electrical insulation and deficient electron transportation mechanism. However, ... -
How context shapes the appropriateness of a robot's voice
(2020)Social robots have a recognizable physical appearance, a distinct voice, and interact with users in specific contexts. Previous research has suggested a 'matching hypothesis', which seeks to rationalise how people judge a ... -
Significance of Crosslinking Approaches in the Development of Next Generation Hydrogels for Corneal Tissue Engineering.
(2021)Medical conditions such as trachoma, keratoconus and Fuchs endothelial dystrophy can damage the cornea, leading to visual deterioration and blindness and necessitating a cornea transplant. Due to the shortage of donor ... -
Investigating the physiological relevance of ex vivo disc organ culture nutrient microenvironments using in silico modeling and experimental validation
(2021)Background: Ex vivo disc organ culture systems have become a valuable tool for the development and pre‐clinical testing of potential intervertebral disc (IVD) regeneration strategies. Bovine caudal discs have been widely ... -
Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues
(2019)The regeneration of complex tissues and organs remains a major clinical challenge. With a view towards bioprinting such tissues, we developed a new class of pore-forming bioink to spatially and temporally control the ... -
Controlled Non‐Viral Gene Delivery in Cartilage and Bone Repair: Current Strategies and Future Directions
(2018)Recent advances in the approval and commercialization of gene therapeutics have fostered the return of gene therapy to center stage. But despite new optimism, no Food and Drug Administration approved product exists for the ... -
A Systematic Review of the Educational Effectiveness of Simulation Used in Open Surgery
(2019)The role of simulation to teach and access open surgical skills has become more prevalent in recent years. This systematic review synthesizes the totality of evidence with respect to the educational effectiveness of ... -
The predictive capacity of the MADYMO ellipsoid pedestrian model for pedestrian ground contact kinematics and injury evaluation
(2021)Pedestrian injuries occur in both the primary vehicle contact and the subsequent ground contact. Currently, no ground contact countermeasures have been implemented and no pedestrian model has been validated for ground ... -
Characteristics of cyclist collisions in Ireland: Analysis of a self-reported survey
(2021)As both a utility mode of transport and recreational activity, cycling has well-known health, environmental, and economic benefits. For these reasons it has been encouraged in many countries, including the Republic of ... -
Development of a performance framework to support the innovation process
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Performance frameworks (PFs) for measuring the innovation process are critical for both research and practice. However, existing PFs neglect performance indicators (PIs) and dimensions relevant to companies' current ... -
3D printed microchannel networks to direct vascularisation during endochondral bone repair
(2018)Bone tissue engineering strategies that recapitulate the developmental process of endochondral ossification offer a promising route to bone repair. Clinical translation of such endochondral tissue engineering strategies ... -
Ultrasonic impact grinding machine tool and process development
(University of Dublin, Trinity College, 2013)Ultrasonic Impact Grinding (UIG) is a mechanical material removal process used to erode holes and cavities in hard and brittle materials such as glass, ceramics, silicon carbide, quartz and ... -
Proposing a performance framework for innovation measurement: an exploratory case-based research
(2021)Purpose: Measurement of the innovation process performance is critical for both managers and researchers. However, existing performance frameworks (PFs) neglect performance indicators (PIs) and dimensions relevant to the ... -
Diffusion tensor imaging and arterial tissue: establishing the influence of arterial tissue microstructure on fractional anisotropy, mean diffusivity and tractography
(2021)In this study we investigated the potential of diffusion tensor imaging (DTI) for providing insight into microstructural changes in arterial tissue by exploring the influence that cell, collagen and elastin content have ... -
Bovine pericardium of high fibre dispersion has high fatigue life and increased collagen content; potentially an untapped source of heart valve leaflet tissue
(2020)Bioprosthetic heart valves (BHVs) are implanted in aortic valve stenosis patients to replace the native, dysfunctional valve. Yet, the long-term performance of the glutaraldehyde-fixed bovine pericardium (GLBP) leaflets ... -
Priming as a strategy to overcome detrimental pH effects on cells for intervertebral disc regeneration.
(2021)Disc disease is characterised by degeneration of the nucleus pulposus (NP), the central gelatinous tissue of the intervertebral disc (IVD). As degeneration progresses, the microenvironment of the IVD becomes more hostile ... -
Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism
(2021)Bone represents the most common site for breast cancer metastasis. Bone is a highly dynamic organ that is constantly adapting to its biophysical environment, orchestrated largely by the resident osteocyte network. Osteocytes ... -
Utilizing Osteocyte Derived Factors to Enhance Cell Viability and Osteogenic Matrix Deposition within IPN Hydrogels.
(2020)Many bone defects arising due to traumatic injury, disease, or surgery are unable to regenerate, requiring intervention. More than four million graft procedures are performed each year to treat these defects making bone ... -
Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte-derived extracellular vesicles
(2020)Bone formation or regeneration requires the recruitment, proliferation, and osteogenic differentiation of stem/stromal progenitor cells. A potent stimulus driving this process is mechanical loading. Osteocytes are ...
