Mechanical, Manufacturing & Biomedical Eng: Recent submissions
Now showing items 241-260 of 952
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Improving the intercellular uptake and osteogenic potency of calcium phosphate via nanocomplexation with the RALA peptide
(2020)Calcium phosphate-base materials (e.g., alpha tri-calcium phosphate (α–TCP)) have been shown to promote osteogenic differentiation of stem/progenitor cells, enhance osteoblast osteogenic activity and mediate in vivo bone ... -
3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects
(2020)Successful osteochondral defect repair requires regenerating the subchondral bone whilst simultaneously promoting the development of an overlying layer of articular cartilage that is resistant to vascularization and ... -
3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration
(2020)Therapeutic growth factor delivery typically requires supraphysiological dosages, which can cause undesirable off-target effects. The aim of this study was to 3D bioprint implants containing spatiotemporally defined patterns ... -
The identification of articular cartilage and growth plate extracellular matrix-specific proteins supportive of either osteogenesis or stable chondrogenesis of stem cells
(2020)Tissue-specific extracellular matrix (ECM) proteins can play a key role in regulating the fate of stem cells and can potentially be utilized for therapeutic applications. Realising this potential requires further ... -
Development of a New Bone¿Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating
(2020)The hierarchical structure of bone plays pivotal roles in driving cell behavior and tissue regeneration and must be considered when designing materials for orthopedic applications. Herein, it is aimed to recapitulate the ... -
A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect
(2020)There is a distinct clinical need for new therapies that provide an effective treatment for large bone defect repair. Herein we describe a developmental approach, whereby constructs are primed to mimic certain aspects of ... -
Solid-State Phase Transformation and Self-Assembly of Amorphous Nanoparticles into Higher-Order Mineral Structures
(2020)Materials science has been informed by nonclassical pathways to crystallization, based on biological processes, about the fabrication of damage-tolerant composite materials. Various biomineralizing taxa, such as stony ... -
Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration
(2019)Large bone defects cannot form a callus and exhibit high complication rates even with the best treatment strategies available. Tissue engineering approaches often use scaffolds designed to match the properties of mature ... -
Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration
(2020)Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden. The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated ... -
Synergistic Effects of Acidic pH and Pro-Inflammatory Cytokines IL-1β and TNF-α for Cell-Based Intervertebral Disc Regeneration
(2020)The intervertebral disc (IVD) relies mainly on diffusion through the cartilaginous endplates (CEP) to regulate the nutrient and metabolites exchange, thus creating a challenging microenvironment. Degeneration of the IVD ... -
Evaporating hydrophilic and superhydrophobic droplets in electric fields
(2021)Evaporating water droplets on a heated substrate are investigated in this work. Specifically, the influences of electric fields are studied in the context of the heat flux distribution beneath the droplets as well as the ... -
Characterization of the Erosion of Soft Tissue by Surgical Mesh In Vitro
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Surgical mesh implants have been extensively used in hernia treatment and pelvic organ procedures, such as organ prolapse and stress urinary incontinence. Since the onset of the use of such implants, major complications ... -
On-site energy generation for a decarbonized Irish manufacturing industry
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)The objective of the thesis is to explore whether it is technically, economically and en-vironmentally feasible for an Irish manufacturing facility to become an energy prosumer, byproducing energy on-site, and decrease the ... -
Local heat transfer to an evaporating superhydrophobic droplet
(2018)The heat flux distribution beneath a superhydrophobic evaporating droplet has been explored. High speed, high resolution infrared thermography was employed to measure the heat transfer characteristics of the evaporating ... -
Electrospray array heat transfer
(2018)Multiple source electrospraying enables higher droplet mass flux and greater cooling coverage area in comparison with its single source counterpart. The local convective heat flux to a multiple source electrospray array ... -
Heat transfer characteristics of single cone-jet electrosprays
(2017)Spray cooling is an attractive proposition for thermal dissipation due to its high efficiency and markedly lower power requirements compared with more conventional air cooling systems. The local convective heat flux to ... -
Analysis of a Wide Range of Commercial Exterior Wood Coatings
(MDPI AG, 2020)This study was focused on measuring the properties of twenty-three commercially available coatings formulated for exterior wood applications. The coatings were characterized by measuring their surface tension, solid content, ... -
Heat flux distribution beneath evaporating hydrophilic and superhydrophobic droplets
(Elsevier BV, 2020)An experimental investigation of the heat and mass transfer to an evaporating hydrophilic water droplet using thin-foil thermography and droplet shape analysis is reported. These results have been compared with that of a ... -
A novel ultra-large flat plate heat pipe manufactured by thermal spray
(Elsevier BV, 2020)An ultra-large flat plate copper heat pipe (180 × 180 mm2) was constructed using a thermal spray technique, and it was then thermally characterized. A porous copper wick was fabricated by using a flame spray torch to deposit ... -
SeMSA: a compact super absorber optimised for broadband, low-frequency noise attenuation
(2020)The attenuation of low-frequency broadband noise in a light, small form-factor is an intractable challenge. In this paper, a new technology is presented which employs the highly efficient visco-thermal loss mechanism of a ...
