Mechanical, Manufacturing & Biomedical Eng: Recent submissions
Now showing items 381-400 of 952
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THEREPI: A therapeutic epicardial reservoir for the treatment of cardiac disease
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)The clinical translation of regenerative therapy for the diseased heart, whether in the form of cells, macromolecules or small molecules, is hampered by several factors: the poor retention and short biological half-life ... -
TRPV4-mediates oscillatory fluid shear mechanotransduction in mesenchymal stem cells in part via the primary cilium
(2018)Skeletal homeostasis requires the continued replenishment of the bone forming osteoblast from a mesenchymal stem cell (MSC) population, a process that has been shown to be mechanically regulated. However, the mechanisms ... -
Mediating human stem cell behaviour via defined fibrous architectures by melt electrospinning writing.
(2018)The architecture within which cells reside is key to mediating their specific functions within the body. In this study, we use melt electrospinning writing (MEW) to fabricate cell micro-environments with various fibrous ... -
Direct mechanical characterization of prostate tissue-a systematic review.
(2018)Background Direct mechanical characterisation of tissue is the application of engineering techniques to biological tissue to ascertain stiffness or elasticity, which can change in response to disease states. A number of ... -
Genomic identification, expression profiling, and functional characterization of CatSper channels in the bovine
(2017)Cation channels of sperm (CatSper) are sperm-specific calcium channels with identified roles in the regulation of sperm function in humans, mice, and horses. We sought to employ a comparative genomics approach to identify ... -
Computational and experimental investigation of bone cell response to mechanical stimuli
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2006)The importance of mechanical loading in maintaining bone quality is well illustrated by the drastic effects of its absence in, for example, microgravity, cast immobilisation or paraplegia. The mechanisms underlying adaptation ... -
Mechanobiology of tissue differentiation during osteochondral defect repair
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)Differentiation can be thought of as a process by which cells and tissues undergo a change in phenotype toward a more specialized form or function. It is the contention of this thesis that tissue differentiation is in some ... -
Failure of cemented hip implants under complex loading : experimental and numerical analysis
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)A new generation of experimental pre-clinical testing methods for cemented hip replacement femoral components have been proposed, and preliminarily validated by comparing a 'good' prosthesis design with a 'bad' prosthesis ... -
Mechanical Assessment of the Risk of Atherosclerotic Plaque Rupture in Carotid Arteries with a Focus on Damage Accumulation
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Carotid atherosclerotic plaque rupture is one of the leading causes of death. Growth and development of atherosclerotic plaque alters the geometry and mechanical environment of the healthy arterial tissue. Supra-physiological ... -
Mechanoregulation algorithms predicting peri-prosthetic bone adaptations
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007)Numerous mechanobiological algorithms have been developed in recent years to simulate biological processes such as bone remodelling and tissue differentiation. However, the implementation of such algorithms for the design ... -
Analysis of noise source mechanisms for a subsonic jet
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2006)Despite advances in engine design, from high bypass to co-axial or lobe shaped nozzles, the problem of jet noise reduction continues to require ongoing research in order to comply with the criteria inherent in environmental ... -
Failure mechanisms in bone - a mechanical and histological study
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2006)Repeated loading causes the development of microdamage in bone and may lead to failure by fatigue. Microdam age in the form of microcracks occurs naturally in bone due to the loads experienced during day-to-day activities, ... -
The effect of cyclic tensile loading and growth factors on the chondrogenic differentiation of bone-marrow derived mesenchymal stem cells in a collagen-glycosaminoglycan scaffold
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007)Adult mesenchymal stem cells (MSCs) offer great potential in tissue engineering applications as they can be directed to differentiate along numerous lineages to produce a range of skeletal tissues, including the chondrogenic ... -
Simulation of bone fracture and cutting using the theory of critical distances
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2008)This work was concerned with the prediction of bone fracture in situations where fracture was initiated in areas of stress concentration. Two conditions were studied: (i) fracture in bones and bone samples weakened by the ... -
Finite element and experimental analysis of dented aircraft panels
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2005)Aircraft fuselage panels are susceptible to low velocity impact damage in the form of "dents" from a variety of in-service sources, such as cargo and service trucks, dropped tools during servicing, walking on "no-step ... -
The effect of bone turnover on bone quality and material properties
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2008)Coined in French in the 1820s as a description of a pathological state of bone tissue, the term osteoporosis made its way into the English language only in the 20th century. Unlike other medical concepts, which have not ... -
An experimental and 3D finite element analysis of a form rolling process
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2005)This thesis investigates a cold forming process called Form Rolling. Form Rolling is an innovative method of producing near-net shape parts, which is being implemented in particular by fastener manufacturers. In this study, ... -
Fracture and fatigue in High Impact Polystyrene : the influence of secondary phase morphology (Rubber Particle Size and Effective Rubber Phase Volume) on fracture and fatigue behaviour in HIPS
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)The subject of the following thesis is the influence of the secondary phase morphology on fracture and fatigue behaviour in High Impact Polystyrene (HIPS). The motivation of the work was the premature failure of parts ... -
Finite element and experimental analysis of the micro-form rolling process
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007)The observations made during this research which, to the best knowledge of the author have not been previously mentioned in literature, were as follows: -- Loss of contact between the die and workpiece when rolling small ...
