Mechanical, Manufacturing & Biomedical Eng: Recent submissions
Now showing items 401-420 of 952
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On the development of scaffolds for bone tissue engineering
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007)Many of the current tissue-engineering scaffold-based strategies have suffered from limited cell depth viability when cultured in vitro, with viable cells existing within the outer 250-500 μm from the fluid-scaffold ... -
Post-menopausal osteoporosis and the effect of remodelling on bone material
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007)This work concerns the relationship between bone and its environment and how changes in this environment affect its mechanical behaviour. More particularly, it concerns how the alteration of this environment following ... -
Development of mechanobiomimetic strategies to drive stem cell behaviour for bone regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)There are a host of cases where clinical intervention must be taken to treat diseased or damaged bone, including severe fractures, defects, tumours requiring tissue removal, and debilitating diseases such as osteoporosis. ... -
Noise source identification for ducted fans
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2006)Understanding combustion noise source mechanisms, designing efficient acoustic liners and optimising active control algorithms for noise reduction requires the identification of the frequency and modal content of the ... -
Biophysical Regulation of Stem Cell Osteogenic Lineage Commitment: A Role for the Cytoskeleton
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Osteoporosis is a debilitating disease characterised by weakened bone architecture due to increased resorption activity of osteoclasts and diminished bone deposition by mesenchymal stem cell (MSC) derived osteoblasts. ... -
Fundamental Insights into Arterial Remodelling; Strain-Mediated Degradation of Arterial Collagen
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Maladaptive remodelling of structurally significant collagen fibres in the arterial wall is believed to play a critical role in the development and progression of degenerative arterial disease. A greater understanding of ... -
Biomechanics of Repair in Invertebrates
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Repair is a ubiquitous process in nature, and it is one of the many features of biological materials that humans are constantly attempting to recreate. Though the process of repair has been studied in mammals, very little ... -
Prediciton of fatigue failure in engineering components using the finite element method
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2000)Prediction of fatigue failure in engineering artefects is becoming increasingly important as we enter the third millennium; more catastrophic fatigue failures will occur as engineers push the limits of design even further ... -
Investigating the applicability of single-channel electroencephalography in cochlear implant patients
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)Hearing impairment affects over 5% of the population worldwide. Namely, about a quarter of a million adults in Ireland are estimated to have permanent hearing impairment due mainly to ageing and/or noise exposure. Cochlear ... -
Two-phase flow and heat transfer in reflux thermosyphons
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2016)Improved cooling technologies are becoming necessary in electronic applications, specifically Radio Frequency Power Amplifiers (RFPA) installed in tower-top Remote Radioheads (RRH). Current methods of cooling are becoming ... -
Investigations into the mechanical properties of insect cuticle
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2016)Insect cuticle is a composite material comprised of chitin fibres embedded in a protein matrix. It performs a wide variety of functions across class Insecta, and as such displays a wide bandwidth of material properties. ... -
A biomechanical analysis of the trunk and spine during paediatric cerebral palsy gait
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)Movement pathologies in the lower limbs of children with cerebral palsy are well established in the literature. However, movement pathologies of the upper body, in particular the trunk, are less well defined. Mechanical ... -
Modulating mechanical cues and oxygen availability to regulate chondrogenesis within MSC laden hydrogels
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)Tissue engineering is a potential alternative to conventional surgical techniques for regenerating damaged tissues that lack the ability to spontaneously repair. MSCs are a promising cell source for tissue engineering ... -
The development of an active implantable neural probe system for chronic use
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)The alleviation of symptoms of debilitating neural conditions via neural probes is an increasingly important area of research. However, the effectiveness of these probes decreases over time due to the formation of a glial ... -
Mechanics of the linea alba and suture-based wound closure
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2016)Over the past thirty years, there has been a dramatic change in the methodology of abdominal surgery. The introduction of digitalisation, miniaturisation, improved optics, novel imaging techniques and computerised information ...
