dc.contributor.advisor | Humphries, Peter | |
dc.contributor.author | Hanrahan, Finnian | |
dc.date.accessioned | 2017-01-18T16:47:16Z | |
dc.date.available | 2017-01-18T16:47:16Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Finnian Hanrahan, 'Modulation of the blood-brain barrier for therapeutic benefit', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2014, pp 335 | |
dc.identifier.other | THESIS 10358 | |
dc.description.abstract | To date this lab has carried out novel work in the area of low-molecular weight (<1 kDa) drug delivery to the retina (Campbell, Nguyen et al. 2009; Tam, Kiang et al. 2010). This work was carried by suppression of claudin-5 (CL5), a tight junction protein expressed on endothelial cells of the inner blood-retina barrier, by delivery of small interfering RNA molecules. Recently this work has been extended to include a limited study on suppression of claudin-5 at the blood-brain barrier (BBB), and this resulted in successful delivery of a low-molecular weight compound to the brain (Campbell, Humphries et al. 2011). The primary goal of the study presented here is to extend this BBB modulation to a comprehensive exploration of the benefits of barrier modulation to conditions affecting the brain. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Genetics | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15662302 | |
dc.subject | Genetics, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Modulation of the blood-brain barrier for therapeutic benefit | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 335 | |
dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/79013 | |