dc.contributor.advisor | Martin, Seamus | |
dc.contributor.author | Delivani, Petrina | |
dc.date.accessioned | 2019-04-29T15:31:12Z | |
dc.date.available | 2019-04-29T15:31:12Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Petrina Delivani, 'Role of CED-9/cl-2 family proteins in mitochondrial fission and fusion dynamics', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2008, pp 221 | |
dc.identifier.other | THESIS 8679 | |
dc.description.abstract | Programmed cell death in the nematode C. elegans is the equivalent process to
human apoptosis. Studying this process in the model organism has led to a
great amount of knowledge about the details of pathway steps and proteins that
are involved. While the system in the worm appears trivial with only four
regulating proteins, in mammalian cells at least twenty proteins are already
involved in the initiation of apoptosis. In this study we set out to investigate
worm cell death proteins in vivo and in vitro. Although many things are already
known, it has never been shown before, where and when the only worm
caspase CED-3 is expressed in vivo. In the first part of our study we initially
wanted to analyze the localization and in vivo expression pattern of CED-3 in C.
elegans worm embryos. Although we employed several commercially available
and self-generated anti-CED-3 antibodies, we were not able to achieve CED-3
staining in worm cells. However, during these experiments we found
reorganization of the mitochondrial network by the expression of CED-9 in HeLa
cells. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Genetics | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb13590327 | |
dc.subject | Genetics, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Role of CED-9/cl-2 family proteins in mitochondrial fission and fusion dynamics | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 221 | |
dc.description.note | TARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
dc.identifier.uri | http://hdl.handle.net/2262/86287 | |