A novel synthesis of Loratadine and studies on Stobbe-like condensation reactions

Abstract

Loratadine is one of the best-selling, non-sedative antihistamines worldwide. Numerous papers have been published in academic and patent literature focussing on improvements or alternatives to the original synthesis of Loratadine and its precursors. The most significant of these synthetic approaches, including the original synthesis of the drug, are outlined in Chapter 1. This is followed by the presentation of a novel strategy to access an important Loratadine precursor, 3-[2'-(m-chlorophenyl)ethyl]picolinic acid, from inexpensive starting materials. The synthesis of this precursor was the first project of this Thesis.