Ruthenium(II)-1,8,-Naphthalimide conjugates as DNA probes and photoreagents

Abstract

This thesis entitled "Ru(II)-1,8-Naphthalimide Conjugates as DNA Probes and Photoreagents" is divided into seven chapters. Chapter 1, the introduction, details the structure of DNA and the different modes by which small molecules interact with it. This is followed by a description of the photophysical and DNA binding properties of polypyridyl Ru(II) complexes from the literature, and the various means that have been employed, to improve their properties for application as DNA probes and photocleavers. Finally, the properties of 1,8-naphthalimide based compounds as anti-cancer agents and DNA photocleavers are discussed. This chapter also describes the aims of the research detailed in each of the subsequent chapters.