Pharmacy and Pharmaceutical Sciences: Recent submissions
Now showing items 221-240 of 622
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Electronic Counselling for Oral Anticoagulant Patients
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Education is an essential part of care for patients taking oral anticoagulants. However, it may be time-consuming for health care providers and overwhelming for patients, and hence sometimes suboptimal. Technology-based ... -
The optimisation, characterisation and platelet compatibility of polymeric nanocarriers loaded with NSAIDs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)There is a constant drive towards improving global health by continuously enhancing the quality of drugs available and the systems to deliver these drugs efficiently in order to treat disease. This thesis focused on the ... -
Investigation of the solid-state, powder flow and tabletability properties of comminuted active pharmaceutical ingredients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)An understanding of the effect of processing on the solid-state properties of active pharmaceutical ingredients (APIs) is essential for product manufacturing success. During product development it is possible to induce ... -
Simulations of hydrodynamics in the paddle dissolution apparatus and dissolution from multi-layered compacts
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)Studies involving the calculation of dissolution rates from individual surfaces of large single component compacts, to assist in the prediction of dissolution rates from simple layered compact systems, revealed that ... -
An investigation to optimise teicoplanin therapy in patients with haematological malignancy and Gram-positive infection
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)This research was prompted by concerns of Tallaght Hospital, a major teaching hospital in Dublin, Ireland, that the dosage regimen for teicoplanin in patients with haematological malignancy was suboptimal. Three studies ... -
Characterisation of the functional role of OCTN1 in the pathogenesis of COPD
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The organic cation transporter (OCTN1) has been reported to play a role in the pathogenesis and development of inflammatory diseases. However, this association remains conflicting. Without fully elucidating the physiological ... -
Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The aetiology of inflammatory bowel disease (IBD) is incompletely understood but it is generally accepted to involve a dysregulated intestinal immune response to commensal microbiota and an increase in intestinal permeability. ... -
Effect of hydrodynamics on dissolution rate of poorly soluble drugs in the flow through apparatus
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009) -
The role of community pharmacists in disease prevention: A study of the delivery of clinical pharmacy services in community pharmacy in Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The Role of Community Pharmacists in Disease Prevention: A Study of the Delivery of Clinical Pharmacy Services in Community Pharmacy in Ireland Susan O Dwyer Aims The overall aim of this research was to explore the role ... -
Do Patients Know How to Use Sublingual Glyceryl Trinitrate?
(2011)Glyceryl trinitrate is a nitrate, a potent coronary vasodilator which exerts its principal benefit by reducing venous return, which reduces left ventricular work. Vasodilation is also associated with the undesired effects ... -
The specialist pharmacist and quality indicators of medication use in the care of people with intellectual disabilities and behaviour disorders
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)Quality Medication Use and the Population with Intellectual Disabilities and Behaviour Disorders. A Modified Delphi Technique to develop Quality Indicators and a Grounded Theory approach to information provided by people ... -
The Gut-Brain Axis in Inflammatory Bowel Disease: Assessment of the Central Inflammatory Response to Dextran Sulfate Sodium-Induced Colitis in Rats
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)Inflammatory bowel disease (IBD) is a chronic relapsing-remitting inflammatory condition of the gastrointestinal (GI) tract. Evidence indicates a comorbidity between IBD and psychological symptoms in patients. It is thought ... -
Phytochemical studies on Choisya x dewitteana 'Aztec Pearl'
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The thesis is introduced with a review of the genus Choisya. Here emphasis is placed on the botany, traditional uses, phytochemistry and ethnopharmacological studies. The main classes of compounds found in the genus are ... -
Targeting the NMDA receptor/NO signalling pathway following L-α aminoadipic acid-induced astrocytic impairment and associated changes in the structural plasticity of neurons
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)This investigation firstly aims to characterise the impact of astrocytic dysfunction on neurons in vitro, specifically the effects of L-α amino adipic acid (L-AAA)-induced astrocytic dysfunction on neurite outgrowth and ...