| dc.contributor.advisor | Rozas, Isobel | |
| dc.contributor.author | O'Donovan, Daniel Hillebrand | |
| dc.date.accessioned | 2019-11-14T10:10:31Z | |
| dc.date.available | 2019-11-14T10:10:31Z | |
| dc.date.issued | 2011 | |
| dc.identifier.citation | Daniel Hillebrand O'Donovan, 'The rational design and synthesis of novel a-2 andrenoceptor antagonists as potential antidepressants', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2011, pp 240 | |
| dc.identifier.other | THESIS 9667 | |
| dc.description.abstract | Depression is one of the leading causes of illness worldwide and has been closely linked to low concentrations of monoaminergic neurotransmitters in the brain. Activation of presynaptic alpha-2 adrenoceptors (a2-AR) by the endogenous ligands noradrenaline (NA) and adrenaline (AD) results in a decrease in the release of monoaminergic neurotransmitters. Therefore, the administration of a2-AR antagonists leads to increased concentrations of brain monoamines and constitutes a viable strategy for the treatment for depression. | |
| dc.format | 1 volume | |
| dc.language.iso | en | |
| dc.publisher | Trinity College (Dublin, Ireland). School of Chemistry | |
| dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15148595 | |
| dc.subject | Chemistry, Ph.D. | |
| dc.subject | Ph.D. Trinity College Dublin. | |
| dc.title | The rational design and synthesis of novel a-2 andrenoceptor antagonists as potential antidepressants | |
| dc.type | thesis | |
| dc.type.supercollection | thesis_dissertations | |
| dc.type.supercollection | refereed_publications | |
| dc.type.qualificationlevel | Doctoral | |
| dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
| dc.rights.ecaccessrights | openAccess | |
| dc.format.extentpagination | pp 240 | |
| dc.description.note | TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie | |
| dc.identifier.uri | http://hdl.handle.net/2262/90484 | |
